Universität zu Köln

Verger, Antoine, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Bauer, Elena K., Lohmann, Philipp ORCID: 0000-0002-5360-046X, Blau, Tobias, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Neumaier, Bernd, Shah, Nadim J., Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2018). Static and dynamic F-18-FET PET for the characterization of gliomas defined by IDH and 1p/19q status. Eur. J. Nucl. Med. Mol. Imaging, 45 (3). S. 443 - 452. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose The molecular features isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion have gained major importance for both glioma typing and prognosis and have, therefore, been integrated in the World Health Organization (WHO) classification in 2016. The aim of this study was to characterize static and dynamic O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) PET parameters in gliomas with or without IDH mutation or 1p/19q co-deletion. Methods Ninety patients with newly diagnosed and untreated gliomas with a static and dynamic F-18-FET PET scan prior to evaluation of tumor tissue according to the 2016 WHO classification were identified retrospectively. Mean and maximum tumor-to-brain ratios (TBRmean/max), as well as dynamic parameters (time-to-peak and slope) of F-18-FET uptake were calculated. Results Sixteen (18%) oligodendrogliomas (IDH mutated, 1p/19q co-deleted), 27 (30%) astrocytomas (IDH mutated only), and 47 (52%) glioblastomas (IDH wild type only) were identified. TBRmean, TBRmax, TTP and slope discriminated between IDH mutated astrocytomas and IDH wild type glioblastomas (P < 0.01). TBRmean showed the best diagnostic performance (cut-off 1.95; sensitivity, 89%; specificity, 67%; accuracy, 81%). None of the parameters discriminated between oligodendrogliomas (IDH mutated, 1p/19q co-deleted) and glioblastomas or astrocytomas. Furthermore, TBRmean, TBRmax, TTP, and slope discriminated between gliomas with and without IDH mutation (p < 0.01). The best diagnostic performance was obtained for the combination of TTP with TBRmax or slope (accuracy, 73%). Conclusion Data suggest that static and dynamic F-18-FET PET parameters may allow determining non-invasively the IDH mutation status. However, IDH mutated and 1p/19q co-deleted oligodendrogliomas cannot be differentiated from glioblastomas and astrocytomas by F-18-FET PET.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Verger, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Bauer, Elena K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-193343
DOI:	10.1007/s00259-017-3846-6
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	45
Number:	3
Page Range:	S. 443 - 452
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; PROGNOSTIC VALUE; GRADE II; RESPONSE ASSESSMENT; SURVIVAL; TUMORS; MRI; CLASSIFICATION; PROCARBAZINE; VINCRISTINE Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19334