Universität zu Köln

Morozov, Vasily, Hansman, Grant ORCID: 0000-0001-8735-4618, Hanisch, Franz-Georg, Schroten, Horst and Kunz, Clemens (2018). Human Milk Oligosaccharides as Promising Antivirals. Mol. Nutr. Food Res., 62 (6). HOBOKEN: WILEY. ISSN 1613-4133

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Abstract

Human milk oligosaccharides (HMOs) are diverse unconjugated carbohydrates that are highly abundant in human breast milk. These glycans are investigated in the context of exhibiting multiple functions in infant growth and development. They seem to provide protection against infectious diseases, including a number of poorly manageable viral infections. Although the potential mechanism of the HMO antiviral protection is rather broad, much of the current experimental work has focused on studying of HMO antiadhesive properties. HMOs may mimic structures of viral receptors and block adherence to target cells, thus preventing infection. Still, the potential of HMOs as a source for new antiviral drugs is relatively unexploited. This can be partly attributed to the extreme complexity of the virus-carbohydrate interactions and technical difficulties in HMO isolation, characterization, and manufacturing procedures. Fortunately, we are currently entering a period of major technological advances that have enabled deeper insights into carbohydrate mediated viral entry, rational selection of HMOs as anti-entry inhibitors, and even evaluation of individual synthetic HMO structures. Here, we provide an up-to-date review on glycan binding studies for rotaviruses, noroviruses, influenza viruses, and human immunodeficiency viruses. We also discuss the preventive and therapeutic potential of HMOs as anti-entry inhibitors and address challenges on the route from fundamental studies to clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morozov, Vasily UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansman, Grant UNSPECIFIED orcid.org/0000-0001-8735-4618 UNSPECIFIED Hanisch, Franz-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroten, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunz, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-193557
DOI:	10.1002/mnfr.201700679
Journal or Publication Title:	Mol. Nutr. Food Res.
Volume:	62
Number:	6
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1613-4133
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD GROUP ANTIGENS; RECEPTOR-BINDING SPECIFICITY; STRUCTURAL BASIS; SIALIC-ACID; DC-SIGN; ROTAVIRUS GASTROENTERITIS; CARBOHYDRATE MICROARRAYS; NOROVIRUS INHIBITION; URINARY-EXCRETION; ESCHERICHIA-COLI Multiple languages Food Science & Technology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19355