Universität zu Köln

Reinhardt, Andre, Thomas, Isabell, Schmauck, Julie, Giernoth, Ralf ORCID: 0000-0003-2282-6586, Schulze, Agnes ORCID: 0000-0003-1316-1367 and Neundorf, Ines ORCID: 0000-0001-6450-3991 (2018). Electron Beam Immobilization of Novel Antimicrobial, Short Peptide Motifs Leads to Membrane Surfaces with Promising Antibacterial Properties. J. Func. Biomater., 9 (1). BASEL: MDPI. ISSN 2079-4983

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Abstract

In this study, the efficacy of electron beam irradiation versus chemical coupling for yielding polyethersulfone (PES) membranes with antibacterial properties was investigated. For the surface coating, a recently discovered lead compound, IL-KKA, comprising a short peptide sequence functionalized with imidazolium groups, was used. For better integration within the membrane, several novel variants of IL-KKA were generated. Membrane immobilization was achieved using different doses of electron beam irradiation and NHS/EDC chemical coupling. Physicochemical characterization of the coated membranes was performed by water contact angle measurements, X-ray photoelectron spectroscopy, and scanning electron microscopy. Our results show that electron beam irradiation is as effective and gentle as chemical coupling using the NHS/EDC method. Moreover, it was demonstrated that the obtained membranes exhibit promising antibacterial activity against B. subtilis. In summary, the technique presented herein might be promising as a template for developing future anti-biofilm devices.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reinhardt, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Isabell UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmauck, Julie UNSPECIFIED UNSPECIFIED UNSPECIFIED Giernoth, Ralf UNSPECIFIED orcid.org/0000-0003-2282-6586 UNSPECIFIED Schulze, Agnes UNSPECIFIED orcid.org/0000-0003-1316-1367 UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-193682
DOI:	10.3390/jfb9010021
Journal or Publication Title:	J. Func. Biomater.
Volume:	9
Number:	1
Date:	2018
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2079-4983
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAPHYLOCOCCUS-AUREUS; IONIC LIQUIDS; BACTERIAL; POLY(ETHERSULFONE); FUNCTIONALIZATION; INHIBITION; ADSORPTION; ATTACHMENT; BIOFILMS; ADHESION Multiple languages Materials Science, Biomaterials Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19368