Universität zu Köln

van Gorkom, Gwendolyn, van Gelder, Michel, Eikema, Dirk-Jan, Blok, Henric-Jan, van Lint, M. T., Koc, Yener, Ciceri, Fabio, Beelen, Dietrich, Chevallier, Patrice, Selleslag, Dominik, Blaise, Didier, Foa, Roberto, Corradini, Paolo ORCID: 0000-0002-9186-1353, Castagna, Luca, Moreno, Carol, Solano, Carlos ORCID: 0000-0003-3702-0817, Mueller, Lutz Peter, Tischer, Johanna, Hilgendorf, Inken ORCID: 0000-0003-2038-9730, Hallek, Michael, Bittenbring, Joerg, Theobald, Matthias, Schetelig, Johannes and Kroeger, Nicolaus (2018). Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT. Bone Marrow Transplant., 53 (3). S. 255 - 264. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). Recently, haploidentical HCT is gaining interest because of better outcomes with post-transplantation cyclophosphamide (PTCY). We analyzed patients with CLL who received an allogeneic HCT with a haploidentical donor and whose data were available in the EBMT registry. In total 117 patients (74% males) were included; 38% received PTCY as GVHD prophylaxis. For the whole study cohort OS at 2 and 5 yrs was 48 and 38%, respectively. PFS at 2 and 5 yrs was 38 and 31%, respectively. Cumulative incidence (CI) of NRM in the whole group at 2 and 5 years were 40 and 44%, respectively. CI of relapse at 2 and 5 yrs were 22 and 26%, respectively. All outcomes were not statistically different in patients who received PTCY compared to other types of GVHD prophylaxis. In conclusion, results of haploidentical HCT in CLL seem almost identical to those with HLA-matched donors. Thereby, haploidentical HCT is an appropriate alternative in high risk CLL patients with a transplant indication but no available HLA-matched donor. Despite the use of PTCY, the CI of relapse seems not higher than observed after HLA-matched HCT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Gorkom, Gwendolyn UNSPECIFIED UNSPECIFIED UNSPECIFIED van Gelder, Michel UNSPECIFIED UNSPECIFIED UNSPECIFIED Eikema, Dirk-Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Blok, Henric-Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED van Lint, M. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koc, Yener UNSPECIFIED UNSPECIFIED UNSPECIFIED Ciceri, Fabio UNSPECIFIED UNSPECIFIED UNSPECIFIED Beelen, Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Chevallier, Patrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Selleslag, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaise, Didier UNSPECIFIED UNSPECIFIED UNSPECIFIED Foa, Roberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Corradini, Paolo UNSPECIFIED orcid.org/0000-0002-9186-1353 UNSPECIFIED Castagna, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Moreno, Carol UNSPECIFIED UNSPECIFIED UNSPECIFIED Solano, Carlos UNSPECIFIED orcid.org/0000-0003-3702-0817 UNSPECIFIED Mueller, Lutz Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Tischer, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilgendorf, Inken UNSPECIFIED orcid.org/0000-0003-2038-9730 UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Bittenbring, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Theobald, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schetelig, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194114
DOI:	10.1038/s41409-017-0023-2
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	53
Number:	3
Page Range:	S. 255 - 264
Date:	2018
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MARROW-TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; ALLOGENEIC TRANSPLANTATION; EUROPEAN-SOCIETY; DONOR TRANSPLANTATION; BLOOD; CLL; MULTICENTER; SURVIVAL Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19411