Universität zu Köln

Duebbers, Martin, Simon, Thorsten, Berthold, Frank, Fischer, Janina, Volland, Ruth, Hero, Barbara and Cernaianu, Grigore (2018). Retrospective analysis of relapsed abdominal high-risk neuroblastoma. J. Pediatr. Surg., 53 (3). S. 558 - 567. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1531-5037

Full text not available from this repository.

Abstract

Background/purpose: The impact of abdominal topography and surgical technique on resectability and local relapse pattern of relapsed abdominal high-risk neuroblastoma (R-HR-NB) is not clearly defined. Methods: A sample of thirty-nine patients with R-HR-NB enrolled in the German neuroblastoma trials between 2001 and 2010 was analyzed retrospectively using surgical and imaging reports. We evaluated resectability and local relapse pattern within 6 standardized abdominal regions, impact of extent of the first resective surgery on overall survival (OS), and of number of operations and a higher cumulative surgical assessment score (C-SAS) on OS after the first event. Results: In the left upper abdomen, rates for tumor persistence and relapse were 45.9% and 13.5% and in the left lower abdomen 27.7% and 8.3%, respectively. OS in months did not differ between complete and incomplete first resections (median (interquartile range): 35 (45.6) vs. 40 (65.4), P = .649). Better OS after the first event was associated with repeated as compared to single surgery (47.7 (64.7) vs. 4.3 (12.5), P = .000), and with higher as compared to lower C-SAS (47.7 (64.3) vs. 7.6 (14.7), P = .002). Conclusions: OS after relapse/progression was not dependent on the extent of first resection. The number of operations was associated with better outcome after event. Type of study: Treatment study. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duebbers, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Volland, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Hero, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernaianu, Grigore UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194397
DOI:	10.1016/j.jpedsurg.2017.09.002
Journal or Publication Title:	J. Pediatr. Surg.
Volume:	53
Number:	3
Page Range:	S. 558 - 567
Date:	2018
Publisher:	W B SAUNDERS CO-ELSEVIER INC
Place of Publication:	PHILADELPHIA
ISSN:	1531-5037
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE 4 NEUROBLASTOMA; SURGICAL-MANAGEMENT; RESECTION; TUMOR; CHEMOTHERAPY; SURVIVAL; SURGERY; TRANSPLANTATION; DIAGNOSIS; EXCISION Multiple languages Pediatrics; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19439