Universität zu Köln

Thevis, Mario, Krug, Oliver, Geyer, Hans, Walpurgis, Katja, Baume, Norbert and Thomas, Andreas ORCID: 0000-0003-1199-0743 (2018). Analytical challenges in sports drug testing. Anal. Bioanal. Chem., 410 (9). S. 2275 - 2282. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1618-2650

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Abstract

Analytical chemistry represents a central aspect of doping controls. Routine sports drug testing approaches are primarily designed to address the question whether a prohibited substance is present in a doping control sample and whether prohibited methods (for example, blood transfusion or sample manipulation) have been conducted by an athlete. As some athletes have availed themselves of the substantial breadth of research and development in the pharmaceutical arena, proactive and preventive measures are required such as the early implementation of new drug candidates and corresponding metabolites into routine doping control assays, even though these drug candidates are to date not approved for human use. Beyond this, analytical data are also cornerstones of investigations into atypical or adverse analytical findings, where the overall picture provides ample reason for follow-up studies. Such studies have been of most diverse nature, and tailored approaches have been required to probe hypotheses and scenarios reported by the involved parties concerning the plausibility and consistency of statements and (analytical) facts. In order to outline the variety of challenges that doping control laboratories are facing besides providing optimal detection capabilities and analytical comprehensiveness, selected case vignettes involving the follow-up of unconventional adverse analytical findings, urine sample manipulation, drug/food contamination issues, and unexpected biotransformation reactions are thematized.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Walpurgis, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Baume, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomas, Andreas UNSPECIFIED orcid.org/0000-0003-1199-0743 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194425
DOI:	10.1007/s00216-018-0934-9
Journal or Publication Title:	Anal. Bioanal. Chem.
Volume:	410
Number:	9
Page Range:	S. 2275 - 2282
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1618-2650
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ROUTINE DOPING CONTROLS; CONTROL URINE SAMPLE; THERAPEUTIC-USE; CONTAMINATION; CLENBUTEROL; METABOLITES; MANIPULATION; AGONISTS; FG-4592; SERUM Multiple languages Biochemical Research Methods; Chemistry, Analytical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19442