Universität zu Köln

Yan, Xin ORCID: 0000-0002-9135-7915, Kononenko, Natalia L., Bruel, Annemarie ORCID: 0000-0003-4833-0888, Thomsen, Jesper Skovhus ORCID: 0000-0001-9386-6679 and Poy, Matthew N. (2018). Neuronal Cell Adhesion Molecule 1 Regulates Leptin Sensitivity and Bone Mass. Calcif. Tissue Int., 102 (3). S. 329 - 337. NEW YORK: SPRINGER. ISSN 1432-0827

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Abstract

The central nervous system is widely known to exert control over our systemic physiology via several mechanisms including the regulation of skeletal metabolism. Neuronal circuits within the hypothalamus have been shown to impact bone mass via leptin-dependent and independent mechanisms; however, the full extent to which the brain controls bone homeostasis is not known. We previously identified cell adhesion molecule1 (Cadm1) as a regulator of body weight and energy homeostasis via its expression in multiple regions of the brain. Here, we show that loss of Cadm1 expression in excitatory neurons results in increased leptin sensitivity in addition to a concomitant reduction in bone mass. Femoral length, bone mineral content, diaphyseal cross-sectional area, and bone strength were all lower in Cadm1-deficient animals. Conversely, inducing expression of Cadm1 in excitatory neurons decreased leptin sensitivity and increased femoral length, bone mineral content, and diaphyseal cross-sectional area. Together, these results illustrate an essential role for this synaptic protein in the neuronal regulation of skeletal bone metabolism.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yan, Xin UNSPECIFIED orcid.org/0000-0002-9135-7915 UNSPECIFIED Kononenko, Natalia L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruel, Annemarie UNSPECIFIED orcid.org/0000-0003-4833-0888 UNSPECIFIED Thomsen, Jesper Skovhus UNSPECIFIED orcid.org/0000-0001-9386-6679 UNSPECIFIED Poy, Matthew N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-195106
DOI:	10.1007/s00223-017-0361-5
Journal or Publication Title:	Calcif. Tissue Int.
Volume:	102
Number:	3
Page Range:	S. 329 - 337
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0827
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENERGY; OBESITY; INSULIN; WEIGHT; BRAIN Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19510