Universität zu Köln

Nowak, Stefan, Neidhart, Johannes, Szendro, Ivan G., Rzezonka, Jonas, Marathe, Rahul and Krug, Joachim ORCID: 0000-0002-2143-6490 (2018). Interaction Analysis of Longevity Interventions Using Survival Curves. Biology-Basel, 7 (1). BASEL: MDPI. ISSN 2079-7737

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Abstract

A long-standing problem in ageing research is to understand how different factors contributing to longevity should be expected to act in combination under the assumption that they are independent. Standard interaction analysis compares the extension of mean lifespan achieved by a combination of interventions to the prediction under an additive or multiplicative null model, but neither model is fundamentally justified. Moreover, the target of longevity interventions is not mean life span but the entire survival curve. Here we formulate a mathematical approach for predicting the survival curve resulting from a combination of two independent interventions based on the survival curves of the individual treatments, and quantify interaction between interventions as the deviation from this prediction. We test the method on a published data set comprising survival curves for all combinations of four different longevity interventions in Caenorhabditis elegans. We find that interactions are generally weak even when the standard analysis indicates otherwise.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nowak, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Neidhart, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Szendro, Ivan G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rzezonka, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Marathe, Rahul UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-195163
DOI:	10.3390/biology7010006
Journal or Publication Title:	Biology-Basel
Volume:	7
Number:	1
Date:	2018
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2079-7737
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19516