Universität zu Köln

Scheel, Jennifer Felicia, Schieber, Katharina, Reber, Sandra, Stoessel, Lisa, Waldmann, Elisabeth ORCID: 0000-0003-3983-9957, Jank, Sabine, Eckardt, Kai-Uwe, Grundmann, Franziska, Vitinius, Frank, de Zwaan, Martina, Bertram, Anna and Erim, Yesim (2018). Psychosocial Variables Associated with Immunosuppressive Medication Non-Adherence after Renal Transplantation. Front. Psychiatry, 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-0640

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Abstract

Introduction: Non-adherence to immunosuppressive medication is regarded as an important factor for graft rejection and loss after successful renal transplantation. Yet, results on prevalence and relationship with psychosocial parameters are heterogeneous. The main aim of this study was to investigate the association of immunosuppressive medication non-adherence and psychosocial factors. Methods: In 330 adult renal transplant recipients (>= 12 months posttransplantation), health-related quality of life, depression, anxiety, social support, and subjective medication experiences were assessed, and their associations with patient-reported non-adherence was evaluated. Results: 33.6% of the patients admitted to be partially non-adherent. Non-adherence was associated with younger age, poorer social support, lower mental, but higher physical health-related quality of life. There was no association with depression and anxiety. However, high proportions of clinically relevant depression and anxiety symptoms were apparent in both adherent and non-adherent patients. Conclusion: In the posttransplant follow-up, kidney recipients with lower perceived social support, lower mental and higher physical health-related quality of life, and younger age can be regarded as a risk group for immunosuppressive medication non-adherence. In follow-up contacts with kidney transplant patients, physicians may pay attention to these factors. Furthermore, psychosocial interventions to optimize immunosuppressive medication adherence can be designed on the basis of this information, especially including subjectively perceived physical health-related quality of life and fostering social support seems to be of importance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheel, Jennifer Felicia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schieber, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Reber, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoessel, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Waldmann, Elisabeth UNSPECIFIED orcid.org/0000-0003-3983-9957 UNSPECIFIED Jank, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckardt, Kai-Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Grundmann, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Vitinius, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED de Zwaan, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertram, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Erim, Yesim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-195961
DOI:	10.3389/fpsyt.2018.00023
Journal or Publication Title:	Front. Psychiatry
Volume:	9
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-0640
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; KIDNEY-TRANSPLANT; SOCIAL SUPPORT; REPORTED ADHERENCE; HEALTH SURVEY; RISK-FACTORS; RECIPIENTS; DEPRESSION; THERAPY; GENDER Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19596