Universität zu Köln

Cullinane, Carleen ORCID: 0000-0001-5833-6605, Deacon, Glen B., Drago, Penny R., Erven, Anja P., Junk, Peter C., Luu, Jenny, Meyer, Gerd, Schmitz, Simon, Ott, Ingo ORCID: 0000-0002-8087-4618, Schur, Julia, Webster, Lorraine K. and Klein, Axel ORCID: 0000-0003-0093-9619 (2018). Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes. Dalton Trans., 47 (6). S. 1918 - 1933. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-9234

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Abstract

New organometallic complexes [M(dppe)(R)(2)] {where M = Pt or Pd, dppe = 1,2-bis(diphenylphosphano) ethane, and R = C6F4H-x (x = 6,5,4), C6F3H2-3,5, C6F3H2-5,6, C6F3H2-3,6, C6F4(OMe)-4, and C6F4(cyclo-C5H10N)-4, the numbers x refer to the positions of the protons in the polyfluoroaryl ligands} were synthesised either through transmetalation from the dichlorido complexes [M(dppe)Cl-2] or through ligand exchange using [M(diene)Cl-2] precursor complexes with diene = 1,5-cyclooctadiene (cod) or 1,5-hexadiene (hex). Alternatively, [M(dppX)Cl(R)] complexes with dppX = dppm (1,1-bis(diphenylphosphano) methane), dppe, dppp (1,3-bis(diphenylphosphano) propane), and dppb (1,4-bis(diphenylphosphano) butane) were prepared in decarboxylation reactions from thallium(I) carboxylates Tl(O2CR). The different preparative methods were compared in terms of yield and purity. Structural and spectroscopic data are reported for the new dppX- and diene-M(R)(2) complexes. Antiproliferative activity was investigated for these new complexes against the HT-29 (colon carcinoma) and MCF-7 (breast adenocarcinoma) cell lines, and the active compounds of this first series together with organometallic dppX or hex Pt-II or Pd-II complexes were then included in cell tests using L1210 (leukaemia cells) and the cisplatin-resistant L1210/DDP cell line. Remarkably, promising antiproliferative results were found for a few Pt-II and Pd-II complexes, while structurally closely related compounds were essentially nontoxic.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cullinane, Carleen UNSPECIFIED orcid.org/0000-0001-5833-6605 UNSPECIFIED Deacon, Glen B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drago, Penny R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Erven, Anja P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Junk, Peter C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luu, Jenny UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Ingo UNSPECIFIED orcid.org/0000-0002-8087-4618 UNSPECIFIED Schur, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Webster, Lorraine K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Axel UNSPECIFIED orcid.org/0000-0003-0093-9619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-195990
DOI:	10.1039/c7dt04615d
Journal or Publication Title:	Dalton Trans.
Volume:	47
Number:	6
Page Range:	S. 1918 - 1933
Date:	2018
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-9234
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RAY CRYSTAL-STRUCTURE; TRANSITION-METAL ORGANOMETALLICS; ANTITUMOR-ACTIVITY; DECARBOXYLATION SYNTHESES; BINDING PROPERTIES; CELLULAR UPTAKE; F-19 NMR; CYTOTOXICITY; DNA; DERIVATIVES Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19599