Universität zu Köln

Zimmer, Philipp, Trebing, Sina, Timmers-Trebing, Ursula, Schenk, Alexander, Paust, Rainer, Bloch, Wilhelm, Rudolph, Roland, Streckmann, Fiona and Baumann, Freerk T. (2018). Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support. Care Cancer, 26 (2). S. 615 - 625. NEW YORK: SPRINGER. ISSN 1433-7339

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Abstract

Physical activity is supposed to decrease mortality of colorectal cancer (CRC) and is suggested to reduce side-effects of the disease and its treatment. However, the knowledge about the influence of exercise interventions on patients suffering from CRC and metastasized CRC (mCRC) is still sparse. One frequently observed side effect in mCRC is chemotherapy-induced peripheral neuropathy (CIPN). This randomized controlled trial investigated the influence of a supervised exercise program on CIPN in mCRC. Thirty patients (stage IV) undergoing outpatient palliative treatment including a median of 23.5 chemotherapy cycles of various regimens were randomly assigned to an intervention or control group (IG, n = 17; CG, n = 13). The IG participated in an eight-week supervised exercise program, including endurance, resistance and balance training (2x/week for 60 min) whereas the CG received written standard recommendations to obtain physical fitness. CIPN was assessed using the FACT/GOG-NTX questionnaire. Moreover, endurance capacity (6MWT), strength (h1RM) and balance (GGT-Reha) were evaluated before (t (0)) and after (t (1)) the intervention as well as after 4 weeks follow-up (t(2)). Neuropathic symptoms remained stable in the IG over time, while CIPN significantly worsened in the CG from t (0) to t (1) and t (0) to t (2). In contrast to the CG, the IG significantly improved in strength and balance function. Changes in CIPN correlated with changes in balance. This is the first investigation showing positive effects of a multimodal exercise program on CIPN, balance and strength on mCRC patients in a palliative setting, thereby consequently increasing patients` quality of life. The results support earlier findings stating a positive influence of balance exercise on CIPN.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Trebing, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmers-Trebing, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Paust, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Streckmann, Fiona UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Freerk T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-196747
DOI:	10.1007/s00520-017-3875-5
Journal or Publication Title:	Support. Care Cancer
Volume:	26
Number:	2
Page Range:	S. 615 - 625
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-7339
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; ADJUVANT CHEMOTHERAPY; PHYSICAL-ACTIVITY; PALLIATIVE CARE; FATIGUE; THERAPY; METAANALYSIS; ASSOCIATION; SURVIVORS; LUNG Multiple languages Oncology; Health Care Sciences & Services; Rehabilitation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19674