Universität zu Köln

Peisker, Canan B., Schueller, Thomas, Peters, Jan ORCID: 0000-0002-0195-5357, Wagner, Ben J., Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Mueller, Ulf J., Visser-Vandewalle, Veerle and Kuhn, Jens (2018). Nucleus Accumbens Deep Brain Stimulation in Patients with Substance Use Disorders and Delay Discounting. Brain Sci., 8 (2). BASEL: MDPI. ISSN 2076-3425

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Abstract

Deep brain stimulation (DBS) of the nucleus accumbens (NAc) shows first promising results in patients with severe substance use disorder (SUD), a patient group known to have deficits in self-control. One facet of self-control is the ability to forego smaller sooner rewards in favor of larger later rewards (delay discounting, DD). The NAc has been suggested to integrate motivational information to guide behavior while the consequences of NAc-DBS on DD are unknown. To this end, nine patients with SUD performed a DD task with DBS on and after a 24 h DBS off period. Furthermore, 18 healthy controls were measured to assess possible alterations in DD in patients with SUD. Our findings implicate that DD was not significantly modulated by NAc-DBS and also that patients with SUD did not differ from healthy controls. While null results must be interpreted with caution, the commonly observed association of impaired DD in SUD might suggest a long-term effect of NAc-DBS that was not sufficiently modulated by a 24 h DBS off period.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peisker, Canan B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schueller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Jan UNSPECIFIED orcid.org/0000-0002-0195-5357 UNSPECIFIED Wagner, Ben J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Mueller, Ulf J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197130
DOI:	10.3390/brainsci8020021
Journal or Publication Title:	Brain Sci.
Volume:	8
Number:	2
Date:	2018
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OBSESSIVE-COMPULSIVE DISORDER; NATIONAL EPIDEMIOLOGIC SURVEY; HEROIN-SEEKING BEHAVIORS; INTER-TEMPORAL CHOICE; NICOTINE DEPENDENCE; CIGARETTE-SMOKING; DECISION-MAKING; DRUG-DEPENDENCE; UNITED-STATES; ADDICTION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19713