Universität zu Köln

Baldermann, Juan Carlos, Hardenacke, Katja, Hu, Xiaochen, Koester, Phillip, Horn, Andreas ORCID: 0000-0002-0695-6025, Freund, Hans-Joachim, Zilles, Karl ORCID: 0000-0002-4705-4175, Sturm, Volker, Visser-Vandewalle, Veerle, Jessen, Frank, Maintz, David and Kuhn, Jens (2018). Neuroanatomical Characteristics Associated With Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer's Disease. Neuromodulation, 21 (2). S. 184 - 191. HOBOKEN: WILEY. ISSN 1525-1403

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Abstract

ObjectivesFirst reports on the application of deep brain stimulation (DBS) of the Nucleus basalis of Meynert (NBM) showed feasibility and safety of the intervention in patients with Alzheimers disease. However, clinical effects vary and the mechanisms of actions are still not well understood. The aim of this study was to characterize neuroimaging changes that are associated with the responsiveness to the treatment. Materials and MethodsWe examined preoperative T1-weighted MR images of ten patients with Alzheimer's disease (AD) treated with DBS of the NBM and correlated the clinical outcome with volumetric differences of cortical thickness. Subsequently, we sought to identify brain regions that carry out the clinical effects by correlating the outcome with streamlines connected to the volume of activated tissue. Clinical assessments at baseline, 6 and 12 months after the intervention included the AD Assessment Scale as well as the mini mental status examination. ResultsA fronto-parieto-temporal pattern of cortical thickness was found to be associated with beneficial outcome. Modulation of streamlines connected to left parietal and opercular cortices was associated with better response to the intervention. ConclusionOur results indicate that patients with less advanced atrophy may profit from DBS of the NBM. We conclude that beneficial effects of the intervention are related to preserved fronto-parieto-temporal interplay.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baldermann, Juan Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardenacke, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Koester, Phillip UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Andreas UNSPECIFIED orcid.org/0000-0002-0695-6025 UNSPECIFIED Freund, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zilles, Karl UNSPECIFIED orcid.org/0000-0002-4705-4175 UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197843
DOI:	10.1111/ner.12626
Journal or Publication Title:	Neuromodulation
Volume:	21
Number:	2
Page Range:	S. 184 - 191
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1525-1403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOREBRAIN ATROPHY; DEMENTIA; PATTERNS; TARGET Multiple languages Medicine, Research & Experimental; Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19784