Universität zu Köln

Meyer, M. F., Meinrath, J., Seehawer, J., Lechner, A., Odenthal, M., Quaas, A., Semrau, R., Huebbers, C. U., Marnitz, S., Buettner, R. and Beutner, D. (2018). The relevance of the lymph node ratio as predictor of prognosis is higher in HPV-negative than in HPV-positive oropharyngeal squamous cell carcinoma. Clin. Otolaryngol., 43 (1). S. 192 - 199. HOBOKEN: WILEY. ISSN 1749-4486

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Abstract

Objectives: Lymph node ratio (LNR) is an established predictor in different entities of carcinoma, including head and neck malignancies. In oropharyngeal squamous cell carcinoma (OPSCC), lymph node involvement differs between human papilloma virus (HPV)-positive and HPV-negative tumours. Herein, we evaluate the impact of HPV association on the concept of LNR. Methods: 88 surgically treated patients were included in this retrospective chart review. HPV-positive and HPV-negative OPSCC were evaluated for prediction of outcome by LNR separately. The endpoints were 5-year overall survival (OS) and recurrence-free survival (RFS). Results: The OS of all patients was 60.1%. In univariate analysis, LNR was a significant predictor of overall survival rate (P=. 008) in OPSCC independently of the HPV status, as well as extracapsular spread (ECS). T-classification was only a significant predictor in the univariate analysis in HPV-positive OPSCC carcinoma. However, in the multivariate analysis LNR remained predictor of prognosis in all OPSCC and in HPV-negative OPSCC. In patients with HPV-positive OPSCC, only T-classification reached significance to predict OS. Conclusion: Prognosis of primarily operated HPV-positive patients might be more dependent on the extent of primary tumour site, whereas prognosis of HPVnegative patients is based more on cervical metastatic spread, represented by LNR.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, M. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meinrath, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seehawer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechner, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Semrau, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebbers, C. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marnitz, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-198130
DOI:	10.1111/coa.12938
Journal or Publication Title:	Clin. Otolaryngol.
Volume:	43
Number:	1
Page Range:	S. 192 - 199
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1749-4486
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOVASCULAR RISK-FACTORS; HEARING-LOSS; HISTOPATHOLOGIC CHANGES; OLDER-ADULTS; DISEASE; IMPAIRMENT; SMOKING; COCHLEA; ASSOCIATION; PROGRESSION Multiple languages Otorhinolaryngology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19813