Universität zu Köln

Laenen, Benjamin, Tedder, Andrew ORCID: 0000-0002-7378-4673, Nowak, Michael D., Torang, Per, Wunder, Jorg, Wotzel, Stefan, Steige, Kim A., Kourmpetis, Yiannis, Odong, Thomas ORCID: 0000-0002-2801-4549, Drouzas, Andreas D., Bink, Marco C. A. M., Agren, Jon ORCID: 0000-0001-9573-2463, Coupland, George ORCID: 0000-0001-6988-4172 and Slotte, Tanja ORCID: 0000-0001-6020-5102 (2018). Demography and mating system shape the genome-wide impact of purifying selection in Arabis alpina. Proc. Natl. Acad. Sci. U. S. A., 115 (4). S. 816 - 822. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

Plant mating systems have profound effects on levels and structuring of genetic variation and can affect the impact of natural selection. Although theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation of deleterious alleles, few studies have empirically tested this prediction using genomic data. Here, we study the effect of mating system on purifying selection by conducting population-genomic analyses on whole-genome resequencing data from 38 European individuals of the arctic-alpine crucifer Arabis alpina. We find that outcrossing and mixed-mating populations maintain genetic diversity at similar levels, whereas highly self-fertilizing Scandinavian A. alpina show a strong reduction in genetic diversity, most likely as a result of a postglacial colonization bottleneck. We further find evidence for accumulation of genetic load in highly self-fertilizing populations, whereas the genome-wide impact of purifying selection does not differ greatly between mixed-mating and outcrossing populations. Our results demonstrate that intermediate levels of outcrossing may allow efficient selection against harmful alleles, whereas demographic effects can be important for relaxed purifying selection in highly selfing populations. Thus, mating system and demography shape the impact of purifying selection on genomic variation in A. alpina. These results are important for an improved understanding of the evolutionary consequences of mating system variation and the maintenance of mixed-mating strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Laenen, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Tedder, Andrew UNSPECIFIED orcid.org/0000-0002-7378-4673 UNSPECIFIED Nowak, Michael D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Torang, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunder, Jorg UNSPECIFIED UNSPECIFIED UNSPECIFIED Wotzel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Steige, Kim A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kourmpetis, Yiannis UNSPECIFIED UNSPECIFIED UNSPECIFIED Odong, Thomas UNSPECIFIED orcid.org/0000-0002-2801-4549 UNSPECIFIED Drouzas, Andreas D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bink, Marco C. A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Agren, Jon UNSPECIFIED orcid.org/0000-0001-9573-2463 UNSPECIFIED Coupland, George UNSPECIFIED orcid.org/0000-0001-6988-4172 UNSPECIFIED Slotte, Tanja UNSPECIFIED orcid.org/0000-0001-6020-5102 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-198559
DOI:	10.1073/pnas.1707492115
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	115
Number:	4
Page Range:	S. 816 - 822
Date:	2018
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DELETERIOUS MUTATIONS; FINITE POPULATIONS; SELF-FERTILIZATION; INBREEDING DEPRESSION; GENETIC CONSEQUENCES; NATURAL-SELECTION; REDUCED EFFICACY; EVOLUTION; LOAD; PLANT Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19855