Universität zu Köln

Ghouse, Shanawaz Mohammed, Polikarpova, Anastasia ORCID: 0000-0002-9788-5057, Muhandes, Lina, Dudeck, Jan, Tantcheva-Poor, Iliana, Hartmann, Karin ORCID: 0000-0002-4595-8226, Lesche, Matthias, Dahl, Andreas ORCID: 0000-0002-2668-8371, Eming, Sabine, Mueller, Werner, Behrendt, Rayk ORCID: 0000-0002-1091-2877 and Roers, Axel (2018). Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors. Cell Reports, 22 (1). S. 27 - 36. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer. We analyzed HPV-induced epithelial hyperplasia and squamous cell carcinoma formation, as well as growth of tumors inoculated into the dermis, in mice lacking skin mast cells. Unexpectedly, the absence of mast cells had no effect on HPV-induced epithelial growth or angiogenesis, on growth kinetics of inoculated tumors, or on the immunological tumor micro-milieu. Thus, the conspicuous recruitment of mast cells into tumor tissues cannot necessarily be equated with important mast cell functions in tumor growth.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ghouse, Shanawaz Mohammed UNSPECIFIED UNSPECIFIED UNSPECIFIED Polikarpova, Anastasia UNSPECIFIED orcid.org/0000-0002-9788-5057 UNSPECIFIED Muhandes, Lina UNSPECIFIED UNSPECIFIED UNSPECIFIED Dudeck, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Tantcheva-Poor, Iliana UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Karin UNSPECIFIED orcid.org/0000-0002-4595-8226 UNSPECIFIED Lesche, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahl, Andreas UNSPECIFIED orcid.org/0000-0002-2668-8371 UNSPECIFIED Eming, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrendt, Rayk UNSPECIFIED orcid.org/0000-0002-1091-2877 UNSPECIFIED Roers, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-199197
DOI:	10.1016/j.celrep.2017.12.010
Journal or Publication Title:	Cell Reports
Volume:	22
Number:	1
Page Range:	S. 27 - 36
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ROLES; ANGIOGENESIS; DEFICIENCY; RESPONSES; ABLATION; MODELS; KIT Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19919