Universität zu Köln

Rosen, Jurij, Blau, Tobias, Grau, Stefan J., Barbe, Michael T., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2018). Extracranial Metastases of a Cerebral Glioblastoma: A Case Report and Review of the Literature. Case Rep. Oncol., 11 (2). S. 591 - 601. BASEL: KARGER. ISSN 1662-6575

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Abstract

The glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has accumulated that points to the rare occurrence of extracranial glioblastoma metastases. We here present a case of a female patient with a known glioblastoma who was detected to harbor multiple metastases in the bones, lung, pleura, liver, mesentery, and the subcutaneous soft tissue. Pathogenetically, these metastatic lesions developed most probably after a local progression of the left temporal glioblastoma through the skull base, thus getting access to the systemic lymphatics. Similar cases of extensive glioblastoma metastization, their putative underlying mechanisms, and implications for clinical care are discussed. (C) 2018 The Author(s) Published by S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rosen, Jurij UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Stefan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-199816
DOI:	10.1159/000492111
Journal or Publication Title:	Case Rep. Oncol.
Volume:	11
Number:	2
Page Range:	S. 591 - 601
Date:	2018
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1662-6575
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRANEURAL METASTASES; MULTIFORME; CONCOMITANT; EXTENSION; ABSENCE; SPREAD Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19981