Universität zu Köln

Folkerts, Ann-Kristin, Dorn, Miriam E., Roheger, Mandy ORCID: 0000-0002-6015-3194, Maassen, Marco, Koerts, Janneke, Tucha, Oliver, Altgassen, Mareike ORCID: 0000-0002-2644-8298, Sack, Alexander T., Smit, Diede, Haarmann, Lena and Kalbe, Elke (2018). Cognitive Stimulation for Individuals with Parkinson's Disease Dementia Living in Long-Term Care: Preliminary Data from a Randomized Crossover Pilot Study. Parkinsons Dis., 2018. LONDON: HINDAWI LTD. ISSN 2042-0080

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Abstract

Background. While the efficacy of cognitive stimulation (CS) has been demonstrated in patients with dementia, no study has included patients with Parkinson's disease dementia (PDD). Objective. For the first time, this randomized crossover pilot study examined the feasibility and potential effects of CS in PDD. Methods. All residents of a PDD-specific long-term care unit in the Netherlands that were eligible for the study (n=12) were randomly allocated to group A (n=6) receiving CS (eight weeks, twice weekly for 60minutes) or group B (n=6) receiving usual care (control group, CG). The CG participated in CS afterwards, resulting in an experimental group (EG), consisting of n=12. Pre- and postassessments and a six-week follow-up (FU) were conducted for cognition, neuropsychiatric symptoms, quality of life (QoL), and activities of daily living (ADL) outcomes. Results. Between-group analysis with difference scores from pre- to posttest revealed a group difference for global cognition (CERAD total score) favoring the EG, with a moderate effect size and a p value just failing to reach statistical significance (p=0.067; r = 0.43). A further statistical trend was observed for neuropsychiatric symptoms, again with a moderate effect size (p=0.075; r = 0.42). Within-group analyses indicated improvement only in the EG with large effects also just failing to reach significance for global cognition (short term, p=0.060; r = 0.70) as well as for depression (long term, p=0.072; r = 0.61). ADL deteriorated significantly at FU in the EG (p=0.014; r = 0.71). Conclusions. Although our data are preliminary due to the small sample size, this study shows that CS is feasible and potentially effective for cognitive and noncognitive outcomes in PDD patients. Randomized controlled trials with larger sample sizes are needed to confirm these promising results.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Folkerts, Ann-Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorn, Miriam E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roheger, Mandy UNSPECIFIED orcid.org/0000-0002-6015-3194 UNSPECIFIED Maassen, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerts, Janneke UNSPECIFIED UNSPECIFIED UNSPECIFIED Tucha, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Altgassen, Mareike UNSPECIFIED orcid.org/0000-0002-2644-8298 UNSPECIFIED Sack, Alexander T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smit, Diede UNSPECIFIED UNSPECIFIED UNSPECIFIED Haarmann, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-199918
DOI:	10.1155/2018/8104673
Journal or Publication Title:	Parkinsons Dis.
Volume:	2018
Date:	2018
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	2042-0080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; FACILITIES; IMPAIRMENT; PEOPLE; SCALE; CERAD Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19991