Universität zu Köln

Lichtenstein, Thorsten, Sprenger, Alina, Weiss, Kilian ORCID: 0000-0003-4295-4585, Slebocki, Karin, Cervantes, Barbara, Karampinos, Dimitrios, Maintz, David, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Henning, Tobias D. and Lehmann, Helmar C. (2018). MRI biomarkers of proximal nerve injury in CIDP. Ann. Clin. Transl. Neurol., 5 (1). S. 19 - 29. HOBOKEN: WILEY. ISSN 2328-9503

Full text not available from this repository.

Abstract

Objective To evaluate the utility of nerve diffusion tensor imaging (DTI), nerve cross-sectional area, and muscle magnetic resonance imaging (MRI) multiecho Dixon for assessing proximal nerve injury in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In this prospective observational cohort study, 11 patients with CIDP and 11 healthy controls underwent a multiparametric MRI protocol with DTI of the sciatic nerve and assessment of muscle proton-density fat fraction of the biceps femoris and the quadriceps femoris muscles by multiecho Dixon MRI. Patients were longitudinally evaluated by MRI, clinical examination, and nerve conduction studies at baseline and after 6 months. Results In sciatic nerves of CIDP patients, mean cross-sectional area was significantly higher and fractional anisotropy value was significantly lower, compared to controls. In contrast, muscle proton-density fat fraction was significantly higher in thigh muscles of patients with CIDP, compared to controls. MRI parameters showed high reproducibility at baseline and 6 months. Interpretation Advanced MRI parameters demonstrate subclinical proximal nerve damage and intramuscular fat accumulation in CIDP. Data suggest DTI and multiecho Dixon MRI might be useful in estimating axonal damage and neurogenic muscle changes in CIDP.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lichtenstein, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprenger, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED orcid.org/0000-0003-4295-4585 UNSPECIFIED Slebocki, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Cervantes, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Karampinos, Dimitrios UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Henning, Tobias D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-199993
DOI:	10.1002/acn3.502
Journal or Publication Title:	Ann. Clin. Transl. Neurol.
Volume:	5
Number:	1
Page Range:	S. 19 - 29
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2328-9503
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFLAMMATORY DEMYELINATING POLYNEUROPATHY; MAGNETIC-RESONANCE; PERIPHERAL-NERVES; MUSCULAR-DYSTROPHY; SKELETAL-MUSCLE; NEUROGRAPHY; POLYRADICULONEUROPATHY; REGENERATION; DISEASE; FAT Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19999