Universität zu Köln

Noormohammadi, Alireza, Calculli, Giuseppe, Gutierrez-Garcia, Ricardo, Khodakarami, Amirabbas, Koyuncu, Seda and Vilchez, David ORCID: 0000-0002-0801-0743 (2018). Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells. Cell. Mol. Life Sci., 75 (2). S. 275 - 291. BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

Protein homeostasis, or proteostasis, is essential for cell function, development, and organismal viability. The composition of the proteome is adjusted to the specific requirements of a particular cell type and status. Moreover, multiple metabolic and environmental conditions challenge the integrity of the proteome. To maintain the quality of the proteome, the proteostasis network monitors proteins from their synthesis through their degradation. Whereas somatic stem cells lose their ability to maintain proteostasis with age, immortal pluripotent stem cells exhibit a stringent proteostasis network associated with their biological function and intrinsic characteristics. Moreover, growing evidence indicates that enhanced proteostasis mechanisms play a central role in immortality and cell fate decisions of pluripotent stem cells. Here, we will review new insights into the melding fields of proteostasis and pluripotency and their implications for the understanding of organismal development and survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Noormohammadi, Alireza UNSPECIFIED UNSPECIFIED UNSPECIFIED Calculli, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutierrez-Garcia, Ricardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Khodakarami, Amirabbas UNSPECIFIED UNSPECIFIED UNSPECIFIED Koyuncu, Seda UNSPECIFIED UNSPECIFIED UNSPECIFIED Vilchez, David UNSPECIFIED orcid.org/0000-0002-0801-0743 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200169
DOI:	10.1007/s00018-017-2602-1
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	75
Number:	2
Page Range:	S. 275 - 291
Date:	2018
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAT-SHOCK PROTEINS; MOLECULAR CHAPERONES; SELF-RENEWAL; NEURAL DIFFERENTIATION; PROTEASOME ACTIVITY; LIFE-SPAN; EUKARYOTIC CHAPERONIN; STRESS DEFENSE; AUTOPHAGY; UBIQUITIN Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20016