Universität zu Köln

Forbes, Carol A., Deshpande, Sohan, Sorio-Vilela, Francesc, Kutikova, Lucie, Duffy, Steven, Gouni-Berthold, Ioanna and Hagstrom, Emil (2018). A systematic literature review comparing methods for the measurement of patient persistence and adherence. Curr. Med. Res. Opin., 34 (9). S. 1613 - 1626. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1473-4877

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Abstract

Objectives: A systematic literature review was conducted comparing different approaches estimating persistence and adherence in chronic diseases with polypharmacy of oral and subcutaneous treatments. Methods: This work followed published guidance on performing systematic reviews. Twelve electronic databases and grey literature sources were used to identify studies and guidelines for persistence and adherence of oral and subcutaneous therapies in hypercholesterolemia, type 2 diabetes, hypertension, osteoporosis and rheumatoid arthritis. Outcomes of interest of each persistence and adherence data collection and calculation method included pros: accurate, easy to use, inexpensive; and cons: inaccurate, difficult to use, expensive. Results: A total of 4158 records were retrieved up to March 2017. We included 16 observational studies, 5 systematic reviews and 7 guidelines, in patients with hypercholesterolemia (n=8), type 2 diabetes (n=4), hypertension (n=2), rheumatoid arthritis (n=1) and mixed patient populations (n=13). Pharmacy and medical records offer an accurate, easy and inexpensive data collection method. Pill count, medication event monitoring systems (MEMs), self-report questionnaires and observer report are easy to use. MEMS and biochemical monitoring tests can be expensive. Proportion of days covered (PDC) was recommended as a gold standard calculation method for long-term treatments. PDC avoids use of days' supply in calculation, hence is more accurate compared to medication possession ratio (MPR) to assess adherence to treatments in chronic diseases. Conclusions: Decisions on what method to use should be based on considerations of the route of medication administration, the resources available, setting and aim of the assessment. Combining different methods may provide wider insights into adherence and persistence, including patient behavior.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Forbes, Carol A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deshpande, Sohan UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorio-Vilela, Francesc UNSPECIFIED UNSPECIFIED UNSPECIFIED Kutikova, Lucie UNSPECIFIED UNSPECIFIED UNSPECIFIED Duffy, Steven UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagstrom, Emil UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200276
DOI:	10.1080/03007995.2018.1477747
Journal or Publication Title:	Curr. Med. Res. Opin.
Volume:	34
Number:	9
Page Range:	S. 1613 - 1626
Date:	2018
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1473-4877
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELF-REPORTED ADHERENCE; MEDICATION ADHERENCE; PREDICTIVE-VALIDITY; NONADHERENCE; QUESTIONNAIRES; THERAPY; DRUGS Multiple languages Medicine, General & Internal; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20027