Bayersdorf, Robert, Fruscalzo, Arrigo ORCID: 0000-0002-8958-6049 and Catania, Francesco
ORCID: 0000-0002-2652-9397
(2018).
Linking autoimmunity to the origin of the adaptive immune system.
Evol. Med. Public Health (1).
S. 2 - 13.
OXFORD:
OXFORD UNIV PRESS.
ISSN 2050-6201
Abstract
In jawed vertebrates, the adaptive immune system (AIS) cooperates with the innate immune system (IIS) to protect hosts from infections. Although targeting non-self-components, the AIS also generates self-reactive antibodies which, when inadequately counter-selected, can give rise to autoimmune diseases (ADs). ADs are on the rise in western countries. Why haven't ADs been eliminated during the evolution of a similar to 500 million-year old system? And why have they become more frequent in recent decades? Self-recognition is an attribute of the phylogenetically more ancient IIS and empirical data compellingly show that some self-reactive antibodies, which are classifiable as elements of the IIS rather then the AIS, may protect from (rather than cause) ADs. Here, we propose that the IIS's self-recognition system originally fathered the AIS and, as a consequence of this relationship, its activity is dampened in hygienic environments. Rather than a mere breakdown or failure of the mechanisms of self-tolerance, ADs might thus arise from architectural constraints.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-200383 | ||||||||||||||||
DOI: | 10.1093/emph/eoy001 | ||||||||||||||||
Journal or Publication Title: | Evol. Med. Public Health | ||||||||||||||||
Number: | 1 | ||||||||||||||||
Page Range: | S. 2 - 13 | ||||||||||||||||
Date: | 2018 | ||||||||||||||||
Publisher: | OXFORD UNIV PRESS | ||||||||||||||||
Place of Publication: | OXFORD | ||||||||||||||||
ISSN: | 2050-6201 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/20038 |
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