Universität zu Köln

Bayersdorf, Robert, Fruscalzo, Arrigo ORCID: 0000-0002-8958-6049 and Catania, Francesco ORCID: 0000-0002-2652-9397 (2018). Linking autoimmunity to the origin of the adaptive immune system. Evol. Med. Public Health (1). S. 2 - 13. OXFORD: OXFORD UNIV PRESS. ISSN 2050-6201

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Abstract

In jawed vertebrates, the adaptive immune system (AIS) cooperates with the innate immune system (IIS) to protect hosts from infections. Although targeting non-self-components, the AIS also generates self-reactive antibodies which, when inadequately counter-selected, can give rise to autoimmune diseases (ADs). ADs are on the rise in western countries. Why haven't ADs been eliminated during the evolution of a similar to 500 million-year old system? And why have they become more frequent in recent decades? Self-recognition is an attribute of the phylogenetically more ancient IIS and empirical data compellingly show that some self-reactive antibodies, which are classifiable as elements of the IIS rather then the AIS, may protect from (rather than cause) ADs. Here, we propose that the IIS's self-recognition system originally fathered the AIS and, as a consequence of this relationship, its activity is dampened in hygienic environments. Rather than a mere breakdown or failure of the mechanisms of self-tolerance, ADs might thus arise from architectural constraints.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bayersdorf, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Fruscalzo, Arrigo UNSPECIFIED orcid.org/0000-0002-8958-6049 UNSPECIFIED Catania, Francesco UNSPECIFIED orcid.org/0000-0002-2652-9397 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200383
DOI:	10.1093/emph/eoy001
Journal or Publication Title:	Evol. Med. Public Health
Number:	1
Page Range:	S. 2 - 13
Date:	2018
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2050-6201
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-CELLS; NATURAL ANTIBODIES; RHEUMATOID-ARTHRITIS; POSITIVE SELECTION; APOPTOTIC CELLS; B-1 CELLS; AUTOANTIBODY PRODUCTION; IGG AUTOANTIBODIES; PROTECTIVE FACTORS; NETWORK THEORY Multiple languages Evolutionary Biology; Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20038