Universität zu Köln

Hellmund, Astrid, Geipel, Annegret, Berg, Christoph, Bald, Rainer and Gembruch, Ulrich ORCID: 0000-0001-8284-4669 (2018). Early Intrauterine Transfusion in Fetuses with Severe Anemia Caused by Parvovirus B19 Infection. Fetal Diagn. Ther., 43 (2). S. 129 - 138. BASEL: KARGER. ISSN 1421-9964

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Abstract

Objective: To describe procedure-related complications and perinatal survival after intrauterine transfusion (IUT) before 20 weeks of gestation in fetuses with severe anemia due to human parvovirus B19 infection. Materials and Methods: A retrospective study was conducted of all fetuses requiring IUT before 20 weeks of gestation in two tertiary referral centers between January 2002 and July 2015. Gestational age (GA) at first IUT, fetal blood sampling results, and presence of hydrops were related to procedure-related complications, fetal death (FD), and perinatal outcome. Results: A total of 93 IUTs was performed on 55 fetuses. The mean GA at first IUT was 16(+6) (13(+0)-19(+6)) weeks. FD occurred in 11 (20.0%) of the 55 fetuses. Overall survival was 80.0% (44/55). Hydrops was present in 38.2% (21/55) and was strongly associated with FD (p = 0.001). There was no difference with regard to FD, hydrops, or hemoglobin concentration at first IUT in fetuses with transfusion before or after 16(+0) weeks. Conclusion: Severe anemia due to parvovirus B19 infection in the early second trimester can be treated successfully by IUT before 20 weeks of gestation in specialized centers with sufficient expertise. (C) 2017 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hellmund, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Bald, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200417
DOI:	10.1159/000477208
Journal or Publication Title:	Fetal Diagn. Ther.
Volume:	43
Number:	2
Page Range:	S. 129 - 138
Date:	2018
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1421-9964
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RED-CELL ALLOIMMUNIZATION; FETAL ANEMIA; DOPPLER ULTRASONOGRAPHY; NONINVASIVE DIAGNOSIS; EXCHANGE-TRANSFUSION; HYDROPIC FETUSES; MANAGEMENT; GESTATION; PREGNANCY; THROMBOCYTOPENIA Multiple languages Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20041