Universität zu Köln

Dafsari, Haidar S., Reker, Paul, Stalinski, Lisa, Silverdale, Monty ORCID: 0000-0002-3295-6897, Rizos, Alexandra, Ashkan, Keyoumars, Barbe, Michael T., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Evans, Julian, Steffen, Julia, Samuel, Michael, Dembek, Till A., Visser-Vandewalle, Veerle, Antonini, Angelo ORCID: 0000-0003-1040-2807, Ray-Chaudhuri, K., Martinez-Martin, Pablo ORCID: 0000-0003-0837-5280 and Timmermann, Lars (2018). Quality of Life Outcome After Subthalamic Stimulation in Parkinson's Disease Depends on Age. Mov. Disord., 33 (1). S. 99 - 108. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Objective: The purpose of this study was to investigate how quality of life outcome after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) depends on age. Methods: In this prospective, open-label, multicenter study including 120 PD patients undergoing bilateral STN-DBS, we investigated the PDQuestionnaire-8 (PDQ-8), Unified PD Rating Scale-III, Scales for Outcomes in PD-motor examination, complications, activities of daily living, and levodopa equivalent daily dose preoperatively and at 5 months follow-up. Significant changes at follow-up were analyzed with Wilcoxon signed-rank test and Bonferroni correction for multiple comparisons. To explore the influence of age post hoc, the patients were classified into 3 age groups (59, 60-69, 70 years). Intragroup changes were analyzed with Wilcoxon signed-rank and intergroup differences with Kruskal-Wallis tests. The strength of clinical responses was evaluated using effect size. Results: The PDQuestionnaire-8, Scales for Outcomes in PD-motor complications, activities of daily living, and levodopa equivalent daily dose significantly improved in the overall cohort and all age groups with no significant intergroup differences. However, PDQuestionnaire-8 effect sizes for age groups 59, 60 to 69, and 70 years, respectively, were strong, moderate, and small. Furthermore, PDQuestionnaire-8 domain analyses revealed that all domains except cognition and emotional well-being significantly improved in patients aged 59 years, whereas only communication, activities of daily living, and stigma improved in patients aged 60-69 years, and activities of daily living and stigma in patients aged 70 years. Conclusions: Although quality of life, motor complications, and activities of daily living significantly improved in all age groups after bilateral STN-DBS, the beneficial effect on overall quality of life was more pronounced and affected a wider range of quality of life domains in younger patients. (C) 2017 International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reker, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Stalinski, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Silverdale, Monty UNSPECIFIED orcid.org/0000-0002-3295-6897 UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Ashkan, Keyoumars UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Evans, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Samuel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonini, Angelo UNSPECIFIED orcid.org/0000-0003-1040-2807 UNSPECIFIED Ray-Chaudhuri, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED orcid.org/0000-0003-0837-5280 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200780
DOI:	10.1002/mds.27222
Journal or Publication Title:	Mov. Disord.
Volume:	33
Number:	1
Page Range:	S. 99 - 108
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; MOTOR COMPLICATIONS; NONMOTOR SYMPTOMS; CONTROLLED-TRIAL; RATING-SCALE; NUCLEUS; NEUROSTIMULATION; SPES/SCOPA Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20078