Universität zu Köln

Verger, Antoine, Stegmayr, Carina ORCID: 0000-0003-4191-8734, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Van Der Gucht, Axel ORCID: 0000-0002-2060-4210, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Shah, Nadim J., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Guedj, Eric and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2018). Evaluation of factors influencing F-18-FET uptake in the brain. NeuroImage-Clin., 17. S. 491 - 498. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

PET using the amino-acid O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) is gaining increasing interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain tumours is based on the standardized uptake value (SUV) and the tumour-to-brain ratio (TBR). The aim of this study was to explore physiological factors that might influence the relationship of SUV of F-18-FET uptake in various brain areas, and thus affect quantification of F-18-FET uptake in brain tumours. Negative F-18-FET PET scans of 107 subjects, showing an inconspicuous brain distribution of F-18-FET, were evaluated retrospectively. Whole-brain quantitative analysis with Statistical Parametric Mapping (SPM) using parametric SUV PET images, and volumes of interest (VOIs) analysis with fronto-parietal, temporal, occipital, and cerebellar SUV background areas were performed to study the effect of age, gender, height, weight, injected activity, body mass index (BMI), and body surface area (BSA). After multivariate analysis, female gender and high BMI were found to be two independent factors associated with increased SUV of F-18-FET uptake in the brain. In women, SUVmean of F-18-FET uptake in the brain was 23% higher than in men (p < 0.01). SUVmean of F-18-FET uptake in the brain was positively correlated with BMI (r = 0.29; p < 0.01). The influence of these factors on SUV of F-18-FET was similar in all brain areas. In conclusion, SUV of F-18-FET in the normal brain is influenced by gender and weakly by BMI, but changes are similar in all brain areas.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Verger, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Stegmayr, Carina UNSPECIFIED orcid.org/0000-0003-4191-8734 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Van Der Gucht, Axel UNSPECIFIED orcid.org/0000-0002-2060-4210 UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Guedj, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200875
DOI:	10.1016/j.nicl.2017.11.005
Journal or Publication Title:	NeuroImage-Clin.
Volume:	17
Page Range:	S. 491 - 498
Date:	2018
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; AMINO-ACID-TRANSPORT; INTENSIVE-CARE-UNIT; HIGH-GRADE GLIOMA; FET PET; UPTAKE KINETICS; RESPONSE ASSESSMENT; TUMORS; MRI Multiple languages Neuroimaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20087