Universität zu Köln

Helm, Katharina, Viol, Kathrin ORCID: 0000-0003-2949-1846, Weiger, Thomas M., Tass, Peter A., Grefkes, Christian ORCID: 0000-0002-1656-720X, del Monte, Damir and Schiepek, Guenter (2018). Neuronal connectivity in major depressive disorder: a systematic review. Neuropsychiatr. Dis. Treat., 14. S. 2715 - 2738. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1178-2021

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Abstract

Background: The causes of major depressive disorder (MDD), as one of the most common psychiatric disorders, still remain unclear. Neuroimaging has substantially contributed to understanding the putative neuronal mechanisms underlying depressed mood and motivational as well as cognitive impairments in depressed individuals. In particular, analyses addressing changes in interregional connectivity seem to be a promising approach to capture the effects of MDD at a systems level. However, a plethora of different, sometimes contradicting results have been published so far, making general conclusions difficult. Here we provide a systematic overview about connectivity studies published in the field over the last decade considering different methodological as well as clinical issues. Methods: A systematic review was conducted extracting neuronal connectivity results from studies published between 2002 and 2015. The findings were summarized in tables and were graphically visualized. Results: The review supports and summarizes the notion of an altered fronto-limbic mood regulation circuitry in MDD patients, but also stresses the heterogeneity of the findings. The brain regions that are most consistently affected across studies are the orbitomedial prefrontal cortex, anterior cingulate cortex, amygdala, hippocampus, cerebellum and the basal ganglia. Conclusion: The results on connectivity in MDD are very heterogeneous, partly due to different methods and study designs, but also due to the temporal dynamics of connectivity. While connectivity research is an important step toward a complex systems approach to brain functioning, future research should focus on the dynamics of functional and effective connectivity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Helm, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Viol, Kathrin UNSPECIFIED orcid.org/0000-0003-2949-1846 UNSPECIFIED Weiger, Thomas M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED del Monte, Damir UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiepek, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-201333
DOI:	10.2147/NDT.S170989
Journal or Publication Title:	Neuropsychiatr. Dis. Treat.
Volume:	14
Page Range:	S. 2715 - 2738
Date:	2018
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	1178-2021
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATE FUNCTIONAL CONNECTIVITY; DEFAULT-MODE NETWORK; TRANSCRANIAL MAGNETIC STIMULATION; WHITE-MATTER ABNORMALITIES; ANTERIOR CINGULATE CORTEX; MEDICATION-NAIVE PATIENTS; RESTING-STATE; PREFRONTAL CORTEX; DRUG-NAIVE; ANTIDEPRESSANT TREATMENT Multiple languages Clinical Neurology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20133