Universität zu Köln

Notara, M., Lentzsch, A., Coroneo, M. and Cursiefen, C. (2018). The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure. Stem Cells Int., 2018. LONDON: HINDAWI LTD. ISSN 1687-9678

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Abstract

The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blood and lymphatic vessels into the cornea. Defects in limbal epithelial stem cells are linked to corneal neovascularisation, including lymphangiogenesis, chronic inflammation, conjunctivalisation, epithelial abnormalities including the presence of goblet cells, breaks in Bowman's membrane, persistent epithelial defects and ulceration, ocular surface squamous neoplasia, lipid keratopathy, pain, discomfort, and compromised vision. It has been postulated that pterygium is an example of focal limbal deficiency. Previous reports showing changes occurring in limbal epithelium during pterygium pathogenesis suggest that there is a link to stem cell damage. In this light, pterygium can serve as a model disease of UV-induced stem cell damage also characterised by corneal blood and lymphangiogenesis. This review focuses on the role of corneal and limbal epithelial cells and the stem cell niche in maintaining corneal avascularity and corneal immune privilege and how this may be deregulated following UV exposure. We present an overview of the PUBMED literature in the field as well as recent work from our laboratories.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Notara, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lentzsch, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coroneo, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202849
DOI:	10.1155/2018/8620172
Journal or Publication Title:	Stem Cells Int.
Volume:	2018
Date:	2018
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1687-9678
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; BASEMENT-MEMBRANE HETEROGENEITY; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; PROGENITOR CELLS; CONTACT-LENSES; FACTOR VEGF; FACTOR-BETA; IMMUNOHISTOCHEMICAL LOCALIZATION; MEDIATED INDUCTION Multiple languages Cell & Tissue Engineering Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20284