Universität zu Köln

Stuckenschneider, Tim ORCID: 0000-0002-0972-4377, Askew, Christopher David, Ruediger, Stefanie ORCID: 0000-0001-6339-6506, Polidori, Maria Cristina, Abeln, Vera, Vogt, Tobias, Krome, Andreas, Rikkert, Marcel Olde, Lawlor, Brian and Schneider, Stefan ORCID: 0000-0002-4563-9890 (2018). Cardiorespiratory Fitness and Cognitive Function are Positively Related Among Participants with Mild and Subjective Cognitive Impairment. J. Alzheimers Dis., 62 (4). S. 1865 - 1876. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: By 2030, about 74 million people will be diagnosed with dementia, and many more will experience subjective (SCI) or mild cognitive impairment (MCI). As physical inactivity has been identified to be a strong modifiable risk factor for dementia, exercise and physical activity (PA) may be important parameters to predict the progression from MCI to dementia, but might also represent disease trajectory modifying strategies for SCI and MCI. Objective: A better understanding of the relationship between activity, fitness, and cognitive function across the spectrum of MCI and SCI would provide an insight into the potential utility of PA and fitness as early markers, and treatment targets to prevent cognitive decline. Methods: 121 participants were stratified into three groups, late MCI (LMCI), early MCI (EMCI), and SCI based on the Montreal Cognitive Assessment (MoCA). Cognitive function assessments also included the Trail Making Test A+B, and a verbal fluency test. PA levels were evaluated with an interviewer-administered questionnaire (LAPAQ) and an activity monitor. An incremental exercise test was performed to estimate cardiorespiratory fitness and to determine exercise capacity relative to population normative data. Results: ANCOVA revealed that LMCI subjects had the lowest PA levels (LAPAQ, p = 0.018; activity monitor, p = 0.041), and the lowest exercise capacity in relation to normative values (p = 0.041). Moreover, a modest correlation between MoCA and cardiorespiratory fitness (r = 0.25; p < 0.05) was found. Conclusion: These findings suggest that during the earliest stages of cognitive impairment PA and exercise capacity might present a marker for the risk of further cognitive decline. This finding warrants further investigation using longitudinal cohort studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stuckenschneider, Tim UNSPECIFIED orcid.org/0000-0002-0972-4377 UNSPECIFIED Askew, Christopher David UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruediger, Stefanie UNSPECIFIED orcid.org/0000-0001-6339-6506 UNSPECIFIED Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Abeln, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogt, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Krome, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rikkert, Marcel Olde UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawlor, Brian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Stefan UNSPECIFIED orcid.org/0000-0002-4563-9890 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-203116
DOI:	10.3233/JAD-170996
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	62
Number:	4
Page Range:	S. 1865 - 1876
Date:	2018
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHYSICAL-ACTIVITY; ALZHEIMERS-DISEASE; REFERENCE VALUES; OLDER-ADULTS; EXERCISE; DEMENTIA; RISK; AGE; PROGRESSION; VALIDATION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20311