Universität zu Köln

Bredart, Anne, Kop, Jean-Luc, Antoniou, Antonis C., Cunningham, Alex P., De Pauw, Antoine, Tischkowitz, Marc ORCID: 0000-0002-7880-0628, Ehrencrona, Hans ORCID: 0000-0002-5589-3622, Dolbeault, Sylvie, Robieux, Leonore ORCID: 0000-0002-7715-7204, Rhiem, Kerstin, Easton, Douglas F., Devilee, Peter ORCID: 0000-0002-8023-2009, Stoppa-Lyonnet, Dominique and Schmutlzer, Rita (2018). Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries. Fam. Cancer, 17 (1). S. 31 - 42. DORDRECHT: SPRINGER. ISSN 1573-7292

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Abstract

The 'BOADICEA' Web Application (BWA) used to assess breast cancer risk, is currently being further developed, to integrate additional genetic and non-genetic factors. We surveyed clinicians' perceived acceptability of the existing BWA v3. An online survey was conducted through the BOADICEA website, and the British, Dutch, French and Swedish genetics societies. Cross-sectional data from 443 participants who provided at least 50% responses were analysed. Respondents varied in age and, clinical seniority, but mainly comprised women (77%) and genetics professionals (82%). Some expressed negative opinions about the scientific validity of BOADICEA (9%) and BWA v3 risk presentations (7-9%). Data entry time (62%), clinical utility (22%) and ease of communicating BWA v3 risks (13-17%) received additional negative appraisals. In multivariate analyses, controlling for gender and country, data entry time was perceived as longer by genetic counsellors than clinical geneticists (p < 0.05). Respondents who (1) considered hormonal BC risk factors as more important (p < 0.01), and (2) communicated numerical risk estimates more frequently (p < 0.001), judged BWA v3 of lower clinical utility. Respondents who carried out less frequent clinical activity (p < 0.01) and respondents with '11 to 15 years' seniority (p < 0.01) had less favourable opinions of BWA v3 risk presentations. Seniority of '6 to 10 years' (p < 0.05) and more frequent numerical risk communication (p < 0.05) were associated with higher fear of communicating the BWA v3 risks to patients. The level of genetics training did not affect opinions. Further development of BWA should consider technological, genetics service delivery and training initiatives.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bredart, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kop, Jean-Luc UNSPECIFIED UNSPECIFIED UNSPECIFIED Antoniou, Antonis C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cunningham, Alex P. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Pauw, Antoine UNSPECIFIED UNSPECIFIED UNSPECIFIED Tischkowitz, Marc UNSPECIFIED orcid.org/0000-0002-7880-0628 UNSPECIFIED Ehrencrona, Hans UNSPECIFIED orcid.org/0000-0002-5589-3622 UNSPECIFIED Dolbeault, Sylvie UNSPECIFIED UNSPECIFIED UNSPECIFIED Robieux, Leonore UNSPECIFIED orcid.org/0000-0002-7715-7204 UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Easton, Douglas F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Devilee, Peter UNSPECIFIED orcid.org/0000-0002-8023-2009 UNSPECIFIED Stoppa-Lyonnet, Dominique UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutlzer, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-204526
DOI:	10.1007/s10689-017-0014-x
Journal or Publication Title:	Fam. Cancer
Volume:	17
Number:	1
Page Range:	S. 31 - 42
Date:	2018
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-7292
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER-RISK-ASSESSMENT; BREAST-CANCER; GUIDE DECISIONS; ONLINE TOOL; PREDICTION; MUTATION; VALIDATION; BRCA1; PANEL; CARE Multiple languages Oncology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20452