Universität zu Köln

Tur, Mehmet Kemal ORCID: 0000-0002-9259-6723, Daramola, Adebukola K., Gattenloehner, Stefan, Herling, Marco, Chetty, Shivan ORCID: 0000-0003-3565-7531 and Barth, Stefan ORCID: 0000-0001-9589-653X (2017). Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins. Biomedicines, 5 (4). BASEL: MDPI. ISSN 2227-9059

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Abstract

Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin's (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tur, Mehmet Kemal UNSPECIFIED orcid.org/0000-0002-9259-6723 UNSPECIFIED Daramola, Adebukola K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gattenloehner, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Chetty, Shivan UNSPECIFIED orcid.org/0000-0003-3565-7531 UNSPECIFIED Barth, Stefan UNSPECIFIED orcid.org/0000-0001-9589-653X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-208316
DOI:	10.3390/biomedicines5040059
Journal or Publication Title:	Biomedicines
Volume:	5
Number:	4
Date:	2017
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2227-9059
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROMOTER METHYLATION; DNA METHYLATION; SIGNAL-TRANSDUCTION; COLORECTAL-CANCER; LUNG-CANCER; DEATH; EXPRESSION; GENE; HYPERMETHYLATION; BINDING Multiple languages Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20831