Universität zu Köln

Herrmann, Jennifer ORCID: 0000-0003-3398-9938, Rybniker, Jan and Mueller, Rolf (2017). Novel and revisited approaches in antituberculosis drug discovery. Curr. Opin. Biotechnol., 48. S. 94 - 102. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0429

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Abstract

The increasing prevalence of multidrug-resistant Mycobacterium tuberculosis (Mtb) necessitates the discovery and development of novel drugs against tuberculosis. In this review, we focus on two recent approaches that led to the discovery of promising antitubercular compound classes: (I) Hits derived from large compound library screens are increasingly difficult to translate into clinical application; this in turn fostered the development of innovative screening methods. (II) An alternative strategy towards high-quality hits and leads is to evaluate chemically diverse scaffolds which can be found among natural products. The so-called rekindling and repurposing approaches were particularly fruitful in the last few years.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herrmann, Jennifer UNSPECIFIED orcid.org/0000-0003-3398-9938 UNSPECIFIED Rybniker, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-208981
DOI:	10.1016/j.copbio.2017.03.023
Journal or Publication Title:	Curr. Opin. Biotechnol.
Volume:	48
Page Range:	S. 94 - 102
Date:	2017
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0429
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NATURAL-PRODUCTS; CLINICAL CANDIDATE; IN-VITRO; TUBERCULOSIS; THERAPY; STREPTOMYCES; ANTIBIOTICS; AGENTS; CAPRAZAMYCINS; SPECTINAMIDES Multiple languages Biochemical Research Methods; Biotechnology & Applied Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20898