Universität zu Köln

Werner, Jan-Michael, Kuhl, Saskia, Stavrinou, Pantelis ORCID: 0000-0001-8653-1395, Roehn, Gabriele, Krischek, Boris, Blau, Tobias, Goldbrunner, Roland and Timmer, Marco (2017). Expression of FAS-L Differs from Primary to Relapsed Low-grade Gliomas and Predicts Progression-free Survival. Anticancer Res., 37 (12). S. 6639 - 6649. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Background/Aim: The tumor necrosis factor FAS is overexpressed in high-grade gliomas (HGG). Only little is known about FAS or FAS ligand (FAS-L) in low-grade gliomas (LGG). We explored FAS/FAS-L expression in LGG, focusing on differences in primary and relapsed LGG and on its prognostic value. Patients and Methods: A total of 133 glioma samples (73 LGG, 60 HGG) were collected. The LGG samples included 15 matched pairs of primary and relapsed tumors. RT-PCR was performed to measure FAS/FAS-L expression, using subunit A, flavoprotein variant (SDHA) as housekeeper. Clinical data included progression free-(PFS) and overall survival (OS). Results: LGG showed significantly lower FAS but higher FAS-L expression than HGG. The FAS-L expression was higher in primary compared to relapsed LGG and had a positive prognostic value concerning PFS (median 45.20 vs. 31.37 months). Conclusion: FAS-L could act as a prognostic marker and potential target in primary LGG.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Werner, Jan-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhl, Saskia UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED orcid.org/0000-0001-8653-1395 UNSPECIFIED Roehn, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Krischek, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Blau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmer, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-209348
DOI:	10.21873/anticanres.12121
Journal or Publication Title:	Anticancer Res.
Volume:	37
Number:	12
Page Range:	S. 6639 - 6649
Date:	2017
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLIOBLASTOMA; APOPTOSIS; DEATH; ASTROCYTOMAS; LIGAND Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20934