Universität zu Köln

Jakobsen, J. R., Mackey, A. L., Knudsen, A. B., Koch, M., Kjaer, M. and Krogsgaard, M. R. (2017). Composition and adaptation of human myotendinous junction and neighboring muscle fibers to heavy resistance training. Scand. J. Med. Sci. Sports, 27 (12). S. 1547 - 1560. HOBOKEN: WILEY. ISSN 1600-0838

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Abstract

The myotendinous junction (MTJ) is a common site of strain injury and yet understanding of its composition and ability to adapt to loading is poor. The main aims of this study were to determine the profile of selected collagens and macrophage density in human MTJ and adjoining muscle fibers, and to investigate whether heavy exercise loading would alter this profile. Fifteen individuals scheduled for anterior cruciate ligament repair surgery were randomized into three groups: control, acute or 4weeks heavy resistance training. MTJ samples were collected from the semitendinosus and gracilis muscles and were sectioned and stained immunohistochemically for collagen types I, III, VI, XII, XIV, XXII, Tenascin-C and CD68. Macrophage density and distribution was evaluated and the amount of each collagen type in muscle and MTJ was graded. Collagen XXII was observed solely at the MTJ, while all other collagens were abundant at the MTJ and in muscle perimysium or endomysium. The endomysial content of collagen XIV, macrophages and Tenascin-C increased following 4weeks of training. These findings illustrate the heterogeneity of collagen type composition of human MTJ. The increase in collagen XIV following 4weeks of training may reflect a training-induced protection against strain injuries in this region.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jakobsen, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mackey, A. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knudsen, A. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kjaer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krogsgaard, M. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-209381
DOI:	10.1111/sms.12794
Journal or Publication Title:	Scand. J. Med. Sci. Sports
Volume:	27
Number:	12
Page Range:	S. 1547 - 1560
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0838
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TISSUE-SPECIFIC EXPRESSION; COLLAGEN-XII; HAMSTRING INJURIES; SPLICE VARIANTS; SOCCER; PERIMYSIUM; ULTRASTRUCTURE; EPIDEMIOLOGY; INTEGRITY; STRAINS Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20938