Universität zu Köln

Schaub, Friederike, Pohl, Layla, Enders, Philip ORCID: 0000-0002-9527-4957, Adler, Werner ORCID: 0000-0001-9791-5407, Bachmann, Bjorn O., Cursiefen, Claus and Heindl, Ludwig M. (2017). Impact of corneal donor lens status on two-year course and outcome of Descemet membrane endothelial keratoplasty (DMEK). Graefes Arch. Clin. Exp. Ophthalmol., 255 (12). S. 2407 - 2415. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

Our purpose was to investigate the impact of lens status of corneal donors on the two-year course and clinical outcome of Descemet membrane endothelial keratoplasty (DMEK). In 181 DMEK surgeries, 136 phakic and 45 pseudophakic donor corneas were grafted. In this retrospective audit we compared the lens status of corneal donors regarding the outcome measures best spectacle-corrected visual acuity (BSCVA), central corneal thickness (CCT), and endothelial cell density (ECD) at 1, 3, 6, 12, and 24 months, as well as intra- and postoperative complication rates and graft detachment rates requiring re-bubbling. Comparing the use of phakic and pseudophakic donor tissue in DMEK surgery, BSCVA results revealed no significant differences during the two-year course (p ae<yen> 0.087). CCT showed significantly lower values at 1 month (553.8 +/- 56 vs. 625.2 +/- 119 mu m; p < 0.001) and 6 months follow-up (530.6 +/- 49.9 vs. 557.3 +/- 47 mu m; p = 0.026) for phakic donor tissue recipients, but were comparable later (p ae<yen> 0.173). ECD values were statistically higher 6 (1915 +/- 390 vs. 1565 +/- 420 cells/mm(2); p < 0.001) and 24 months postoperatively (1772 +/- 384 vs. 1375 +/- 377 cells/mm(2); p = 0.030) in phakic donor tissue recipients. Mixed regression analyses demonstrated a significant association between ECD results and donor lens status (p = 0.029) and donor ECD (p = 0.028), but donor age did not show significant influence (p = 0.241). ECD is higher in phakic corneal donors and appears to remain at a higher level during the course resulting in initially faster reduction of corneal edema compared to pseudophakic DMEK grafts. Nevertheless, pseudophakic transplants with high ECD seem to produce comparable functional results in recipients after a two year course.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Pohl, Layla UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Adler, Werner UNSPECIFIED orcid.org/0000-0001-9791-5407 UNSPECIFIED Bachmann, Bjorn O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-209771
DOI:	10.1007/s00417-017-3827-2
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	255
Number:	12
Page Range:	S. 2407 - 2415
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-LOSS; TISSUE; TIME; AGE Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20977