Universität zu Köln

Roehr, Susanne ORCID: 0000-0001-9385-0669, Luck, Tobias ORCID: 0000-0001-7551-4397, Pabst, Alexander, Bickel, Horst, Koenig, Hans-Helmut, Luehmann, Dagmar, Fuchs, Angela, Wolfsgruber, Steffen, Wiese, Birgitt, Weyerer, Siegfried, Moesch, Edelgard, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Mallon, Tina, Pentzek, Michael, Wagner, Michael ORCID: 0000-0003-2589-6440, Mamone, Silke, Werle, Jochen, Scherer, Martin, Maier, Wolfgang, Jessen, Frank and Riedel-Heller, Steffi G. (2017). Subjective cognitive decline is longitudinally associated with lower health-related quality of life. Int. Psychogeriatr., 29 (12). S. 1939 - 1951. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1741-203X

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Abstract

Background: Subjective cognitive decline (SCD), the potentially earliest notable manifestation of preclinical Alzheimer's disease and other dementias, was consistently associated with lower quality of life in cross-sectional studies. The aim of this study was to investigate whether such an association persists longitudinally - particularly with health-related quality of life (HRQoL) in older individuals without cognitive impairment. Methods: Data were derived from follow-up 2-6 of the prospective Germany Study on Ageing, Cognition and Dementia in Primary Care (AgeCoDe) covering a total six-year observation period. We used linear mixed effects models to estimate the effect of SCD on HRQoL measured by the EQ-5D visual analogue scale (EQ VAS). Results: Of 1,387 cognitively unimpaired individuals aged 82.2 years (SD = 3.2) on average, 702 (50.6%) reported SCD and 230 (16.6%) with SCD-related concerns. Effect estimates of the linear mixed effects models revealed lower HRQoL in individuals with SCD (unadjusted: -3.7 points on the EQ VAS, 95%CI = -5.3 to -2.1; SE = 0.8; p < 0.001; adjusted: -2.9 points, 95%CI = -3.9 to -1.9; SE = 0.5; p < 0.001) than in individuals without SCD. The effect was most pronounced in SCD with related concerns (unadjusted: -5.4, 95%CI = -7.6 to -3.2; SE = 1.1; p < 0.001; adjusted: -4.3, 95%CI = -5.8 to -2.9, SE = 0.7; p < 0.001). Conclusion: SCD constitutes a serious issue to older cognitively unimpaired individuals that is depicted in persisting lower levels of HRQoL beyond depressive symptoms and functional impairment. Therefore, SCD should be taken seriously in clinical practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roehr, Susanne UNSPECIFIED orcid.org/0000-0001-9385-0669 UNSPECIFIED Luck, Tobias UNSPECIFIED orcid.org/0000-0001-7551-4397 UNSPECIFIED Pabst, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Luehmann, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Birgitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesch, Edelgard UNSPECIFIED UNSPECIFIED UNSPECIFIED Brettschneider, Christian UNSPECIFIED orcid.org/0000-0002-5280-1075 UNSPECIFIED Mallon, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Mamone, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Werle, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210176
DOI:	10.1017/S1041610217001399
Journal or Publication Title:	Int. Psychogeriatr.
Volume:	29
Number:	12
Page Range:	S. 1939 - 1951
Date:	2017
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1741-203X
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MINI-MENTAL-STATE; MEMORY COMPLAINTS; DEMENTIA; IMPAIRMENT; DEPRESSION; RISK; MCI Multiple languages Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry; Psychology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21017