Universität zu Köln

Mang, Hyunggon ORCID: 0000-0001-6366-1314, Feng, Baomin, Hu, Zhangjian, Boisson-Dernier, Aurelien ORCID: 0000-0002-9790-3710, Franck, Christina M., Meng, Xiangzong, Huang, Yanyan, Zhou, Jinggeng, Xu, Guangyuan, Wang, Taotao, Shan, Libo and He, Ping ORCID: 0000-0002-5926-8349 (2017). Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases. Plant Cell, 29 (12). S. 3140 - 3157. ROCKVILLE: AMER SOC PLANT BIOLOGISTS. ISSN 1532-298X

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Abstract

Plants have evolved two tiers of immune receptors to detect infections: cell surface-resident pattern recognition receptors (PRRs) that sense microbial signatures and intracellular nucleotide binding domain leucine-rich repeat (NLR) proteins that recognize pathogen effectors. How PRRs and NLRs interconnect and activate the specific and overlapping plant immune responses remains elusive. A genetic screen for components controlling plant immunity identified ANXUR1 (ANX1), a malectin-like domain-containing receptor-like kinase, together with its homolog ANX2, as important negative regulators of both PRR-and NLR-mediated immunity in Arabidopsis thaliana. ANX1 constitutively associates with the bacterial flagellin receptor FLAGELLIN-SENSING2 (FLS2) and its coreceptor BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1). Perception of flagellin by FLS2 promotes ANX1 association with BAK1, thereby interfering with FLS2-BAK1 complex formation to attenuate PRR signaling. In addition, ANX1 complexes with the NLR proteins RESISTANT TO PSEUDOMONAS SYRINGAE2 (RPS2) and RESISTANCE TO P. SYRINGAE PV MACULICOLA1. ANX1 promotes RPS2 degradation and attenuates RPS2-mediated cell death. Surprisingly, a mutation that affects ANX1 function in plant immunity does not disrupt its function in controlling pollen tube growth during fertilization. Our study thus reveals a molecular link between PRR and NLR protein complexes that both associate with cell surface-resident ANX1 and uncovers uncoupled functions of ANX1 and ANX2 during plant immunity and sexual reproduction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mang, Hyunggon UNSPECIFIED orcid.org/0000-0001-6366-1314 UNSPECIFIED Feng, Baomin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Zhangjian UNSPECIFIED UNSPECIFIED UNSPECIFIED Boisson-Dernier, Aurelien UNSPECIFIED orcid.org/0000-0002-9790-3710 UNSPECIFIED Franck, Christina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meng, Xiangzong UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Yanyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Jinggeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Guangyuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Taotao UNSPECIFIED UNSPECIFIED UNSPECIFIED Shan, Libo UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Ping UNSPECIFIED orcid.org/0000-0002-5926-8349 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210402
DOI:	10.1105/tpc.17.00464
Journal or Publication Title:	Plant Cell
Volume:	29
Number:	12
Page Range:	S. 3140 - 3157
Date:	2017
Publisher:	AMER SOC PLANT BIOLOGISTS
Place of Publication:	ROCKVILLE
ISSN:	1532-298X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Botanical Institute
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESISTANCE PROTEINS; DISEASE RESISTANCE; CYTOPLASMIC KINASE; RALF PEPTIDE; HOST TARGET; ARABIDOPSIS; FERONIA; PERCEPTION; COMPLEX; FLS2 Multiple languages Biochemistry & Molecular Biology; Plant Sciences; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21040