Universität zu Köln

Hilgard, Doerte, Konrad, Katja, Meusers, Michael, Bartus, Bela, Otto, Klaus-Peter, Lepler, Rudolf, Schober, Edith, Bollow, Esther and Holl, Reinhard W. (2017). Comorbidity of attention deficit hyperactivity disorder and type 1 diabetes in children and adolescents: Analysis based on the multicentre DPV registry. Pediatr. Diabetes, 18 (8). S. 706 - 714. HOBOKEN: WILEY. ISSN 1399-5448

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Abstract

BackgroundThe interaction between type 1 diabetes mellitus (T1DM) and attention deficit hyperactivity disorder (ADHD) in children and adolescents has been studied rarely. We aimed to analyse metabolic control in children and adolescents with both T1DM and ADHD compared to T1DM patients without ADHD. Patients and methodsAuxological and treatment data from 56.722 paediatric patients (<20 years) with T1DM in the multicentre DPV (Diabetes Prospective Follow-up Initiative) registry were analysed. T1DM patients with comorbid ADHD were compared to T1DM patients without ADHD using multivariable mixed regression models adjusting for demographic confounders. ResultsWe identified 1.608 (2.83%) patients with ADHD, 80.8% were male. Patients with comorbid ADHD suffered twice as often from diabetic ketoacidosis compared to patients without ADHD [10.2; 9.7-10.8 vs [5.4; 5.3-5.4] (P < .0001). We also found significant differences in HbA1c [8.6% (7.3-9.4); 66.7 mmol/mol (56.3-79.4) vs 7.8% (7.0-9.0); 62.1 mmol/mol (53.2-74.7)], insulin dose/kg [0.9 IU/kg (0.7-1.1) vs 0.8 IU/kg (0.7-1.0)], body mass index-standard deviation score (BMI-SDS) [0.2 (-0.5 to 0.8) vs 0.3 (-0.3 to 0.9)], body weight-SDS [0.1 (-0.5 to 0.8) vs 0.3 (0.3 - 0.9)]; (all P < 0.0001), and systolic blood pressure after adjustment [mean: 116.3 vs 117.1 mm Hg)]; (P < 0.005). ConclusionPaediatric patients with ADHD and T1DM showed poor metabolic control compared to T1DM patients without ADHD. Closer cooperation between specialized paediatric diabetes teams and paediatric psychiatry/psychology seems to be necessary to improve diabetes care and metabolic control in this group of patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hilgard, Doerte UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Meusers, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartus, Bela UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Klaus-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Lepler, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Schober, Edith UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollow, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210631
DOI:	10.1111/pedi.12431
Journal or Publication Title:	Pediatr. Diabetes
Volume:	18
Number:	8
Page Range:	S. 706 - 714
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-5448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEFICIT/HYPERACTIVITY DISORDER; METABOLIC-CONTROL; ASSOCIATION; PREDICTORS; GERMANY; KETOACIDOSIS; ADULTS; ADHD Multiple languages Endocrinology & Metabolism; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21063