Universität zu Köln

Grill, Sabine, Yahiaoui-Doktor, Maryam ORCID: 0000-0002-3321-1598, Dukatz, Ricarda, Lammert, Jacqueline ORCID: 0000-0002-0380-574X, Ullrich, Mirjam, Engel, Christoph ORCID: 0000-0002-7247-282X, Pfeifer, Katharina, Basrai, Maryam, Siniatchkin, Michael, Schmidt, Thorsten, Weisser, Burkhard, Rhiem, Kerstin, Ditsch, Nina, Schmutzler, Rita, Bischoff, Stephan C., Halle, Martin and Kiechle, Marion (2017). Smoking and physical inactivity increase cancer prevalence in BRCA-1 and BRCA-2 mutation carriers: results from a retrospective observational analysis. Arch. Gynecol. Obstet., 296 (6). S. 1135 - 1145. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

Background The aim of this analysis in a pilot study population was to investigate whether we can verify seemingly harmful lifestyle factors such as nicotine and alcohol indulgence, obesity, and physical inactivity, as well as a low socioeconomic status for increased cancer prevalence in a cohort of BRCA 1 and 2 mutation carriers. Methods The analysis data are derived from 68 participants of the lifestyle intervention study LIBRE-1, a randomized, prospective trial that aimed to test the feasibility of a lifestyle modification in BRCA 1 and 2 mutation carriers. At study entry, factors such as medical history, lifestyle behavior, and socioeconomic status were retrospectively documented by interview and the current BMI was determined by clinical examination. The baseline measurements were compared within the cohort, and presented alongside reference values for the German population. Results Study participants indicating a higher physical activity during their adolescence showed a significantly lower cancer prevalence (p = 0.019). A significant difference in cancer occurrence was observed in those who smoked prior to the disease, and those who did not smoke (p < 0.001). Diseased mutation carriers tended to have a lower BMI compared to non-diseased mutation carriers (p = 0.079), whereas non-diseased revealed a significantly higher physical activity level than diseased mutation carriers (p = 0.046). Discussion The present data in this small cohort of 68 mutation carriers suggest that smoking and low physical activity during adolescence are risk factors for developing breast cancer in women with BRCA1 or BRCA2 mutation. Further data of the ongoing LIBRE 2 study are necessary to confirm these findings in a larger cohort of 600 mutation carriers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grill, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Yahiaoui-Doktor, Maryam UNSPECIFIED orcid.org/0000-0002-3321-1598 UNSPECIFIED Dukatz, Ricarda UNSPECIFIED UNSPECIFIED UNSPECIFIED Lammert, Jacqueline UNSPECIFIED orcid.org/0000-0002-0380-574X UNSPECIFIED Ullrich, Mirjam UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Christoph UNSPECIFIED orcid.org/0000-0002-7247-282X UNSPECIFIED Pfeifer, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Basrai, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Siniatchkin, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Weisser, Burkhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ditsch, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischoff, Stephan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Halle, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiechle, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210661
DOI:	10.1007/s00404-017-4546-y
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	296
Number:	6
Page Range:	S. 1135 - 1145
Date:	2017
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BREAST-CANCER; OVARIAN-CANCER; ALCOHOL-CONSUMPTION; BODY-WEIGHT; RISK; METAANALYSIS; PATTERNS; ESTROGEN; HISTORY; COHORT Multiple languages Obstetrics & Gynecology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21066