Universität zu Köln

Guerra-Garcia, Pilar ORCID: 0000-0002-7740-0614, Hirsch, Steffen, Levine, Daniel S. and Taj, Mary M. (2017). Preliminary experience on the use of PET/CT in the management of pediatric post-transplant lymphoproliferative disorder. Pediatr. Blood Cancer, 64 (12). HOBOKEN: WILEY. ISSN 1545-5017

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Abstract

Introduction: Post-transplant lymphoproliferative disorder (PTLD) is a well-known complication following prolonged immunosuppression. Contrary to other lymphomas, there is no standardized imaging approach to assess PTLD either at staging or for response to therapy. Positron emission tomography/computed tomography (PET/CT) is an imaging modality that has proven to be useful in lymphoma. However, there is still limited data concerning its use in pediatric PTLD. Our study evaluates the use of PET/CT in pediatric PTLD at our institution. Methods: To assess the role of PET/CT in pediatric PTLD, we reviewed the pediatric patients with PTLD who had undergone PET/CT at our institution between 2000 and 2016. Results: Nine patients were identified. Six had PET/CT at diagnosis. All lesions seen on CT were identified with PET/CT. Fourteen PET/CTs were done during treatment. Eight PET/CTs were negative, including three where CT showed areas of uncertain significance. In these cases, PET/CT helped us to stop treatment and the patients remain in remission after a long follow-up (mean 74.3 months; range 12.4-180.9 months). PET/CT revealed additional disease in two cases, therefore treatment was intensified. Six biopsies and close follow-up was done to confirm PET/CT results. In one case, PET/CT did not identify central nervous system involvement demonstrated on magnetic resonance imaging. Conclusion: PET/CT may have an important role in the staging and follow-up of pediatric PTLD. In our cohort, PET/CT was helpful in staging and assessing treatment response and in clarifying equivocal findings on other imaging modalities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Guerra-Garcia, Pilar UNSPECIFIED orcid.org/0000-0002-7740-0614 UNSPECIFIED Hirsch, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Levine, Daniel S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Taj, Mary M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-210756
DOI:	10.1002/pbc.26685
Journal or Publication Title:	Pediatr. Blood Cancer
Volume:	64
Number:	12
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1545-5017
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; SOLID-ORGAN TRANSPLANTATION; LOW-DOSE CHEMOTHERAPY; FDG-PET; DISEASE PTLD; LYMPHOMA Multiple languages Oncology; Hematology; Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21075