Universität zu Köln

Dolatyari, Mahboubeh, Rostami, Ali, Torabi, Pouneh and Klein, Axel ORCID: 0000-0003-0093-9619 (2017). Fluorescence Resonance Energy Transfer between an Anti-EGFR Antibody and Bi2Se3/SiO2, ZnS/SiO2, and ZnSe/SiO2 Nanomaterials for Biosensor Purposes. Z. Anorg. Allg. Chem., 643 (21). S. 1564 - 1572. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1521-3749

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Abstract

Bi2Se3, ZnS, and ZnSe nanoparticles were synthesized and their surface modified using tetraethyl orthosilicate and (3-aminopropyl) tetraethyl orthosilicate. They were conjugated to an anti-EGFR antibody. SEM images indicate that the sizes of the modified nanoparticles (NPs) Bi2Se3/SiO2, ZnS/SiO2, and ZnSe/SiO2 are about 20 nm. Forster-Fluorescence resonance energy transfer (FRET) between the anti-EGFR antibody and ZnS/SiO2, ZnSe/SiO2, and Bi2Se3/SiO2 nano-materials was investigated in-depth showing e.g. that with conjugation of the anti-EGFR to nanomaterials, fluorescence intensity increases. This increase reaches up to 6.6 times for ZnS/SiO2-anti-EGFR conjugate NPs making their sensitivity attractive for biosensor applications. Fluorescence lifetimes were also increased for all conjugated NPs with markedly higher lifetime for Bi2Se3/SiO2 compared with ZnS/SiO2 and ZnSe/SiO2.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dolatyari, Mahboubeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Rostami, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Torabi, Pouneh UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Axel UNSPECIFIED orcid.org/0000-0003-0093-9619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211146
DOI:	10.1002/zaac.201700257
Journal or Publication Title:	Z. Anorg. Allg. Chem.
Volume:	643
Number:	21
Page Range:	S. 1564 - 1572
Date:	2017
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1521-3749
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEMICONDUCTOR QUANTUM DOTS; FRET; NANOPARTICLES; THERAPY; SYSTEMS; BIOCOMPATIBILITY; BIOCONJUGATION; CHEMISTRY; PROTEINS; CDSE/ZNS Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21114