Universität zu Köln

Gomes, Iva ORCID: 0000-0002-1593-301X, Pereira, Placido J. P., Harms, Sonja ORCID: 0000-0002-3362-3832, Oliveira, Andrea M., Schneider, Peter M. ORCID: 0000-0003-0744-2349 and Brehm, Antonio (2017). Genetic characterization of Guinea-Bissau using a 12 X-chromosomal STR system: Inferences from a multiethnic population. Forensic Sci. Int.-Genet., 31. S. 89 - 95. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-0326

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Abstract

A male West African sample from Guinea-Bissau (West-African coast) was genetically analyzed using 12 X chromosomal short tandem repeats that are grouped into four haplotype groups. Linkage disequilibrium was tested (p <= 0.0008) and association was detected for the majority of markers in three out of the four studied haplotype clusters. The sample of 332 unrelated individuals analyzed in this study belonged to several recognized ethnic groups (n = 18) which were used to evaluate the genetic variation of Guinea-Bissau's population. Pairwise genetic distances (F-ST) did not reveal significant differences among the majority of groups. An additional 110 samples from other countries also belonging to West Africa were as well compared with the sample of Guinea-Bissau. No significant differences were found between these two groups of West African individuals, supporting the genetic homogeneity of this region on the X chromosome level. The generation of over 100 DNA West African sequences provided new insights into the repeat sequence structure of some of the present X-STRs. Parameters for forensic evaluation were also calculated for each X-STR, supporting the potential application of these markers in typical kinship scenarios. Also, the high power of discrimination values for samples of female and male origin observed in this study, confirms the usefulness of the present X-STRs in identification analysis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gomes, Iva UNSPECIFIED orcid.org/0000-0002-1593-301X UNSPECIFIED Pereira, Placido J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Harms, Sonja UNSPECIFIED orcid.org/0000-0002-3362-3832 UNSPECIFIED Oliveira, Andrea M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Peter M. UNSPECIFIED orcid.org/0000-0003-0744-2349 UNSPECIFIED Brehm, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211762
DOI:	10.1016/j.fsigen.2017.08.016
Journal or Publication Title:	Forensic Sci. Int.-Genet.
Volume:	31
Page Range:	S. 89 - 95
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-0326
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MARKERS; REGION; POLYMORPHISMS; DXS10134; PURPOSES; PROFILE; LOCI; KIT Multiple languages Genetics & Heredity; Medicine, Legal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21176