Universität zu Köln

Hoeink, Anna Janina, Schuelke, Christoph, Koch, Raphael, Loehnert, Annika, Kammerer, Sara, Fortkamp, Rasmus, Heindel, Walter and Buerke, Boris (2017). Response Evaluation of Malignant Liver Lesions After TACE/SIRT: Comparison of Manual and Semi-Automatic Measurement of Different Response Criteria in Multislice CT. Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr., 189 (11). S. 1067 - 1076. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-9010

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Abstract

Purpose To compare measurement precision and interobserver variability in the evaluation of hepatocellular carcinoma (HCC) and liver metastases in MSCT before and after transarterial local ablative therapies. Materials and Methods Retrospective study of 72 patients with malignant liver lesions (42 metastases; 30 HCCs) before and after therapy (43 SIRT procedures; 29 TACE procedures). Established (LAD; SAD; WHO) and vitality-based parameters (mRECIST; mLAD; mSAD; EASL) were assessed manually and semi-automatically by two readers. The relative interobserver difference (RID) and intraclass correlation coefficient (ICC) were calculated. Results The median RID for vitality-based parameters was lower from semi-automatic than from manual measurement of mLAD (manual 12.5 %; semi-automatic 3.4 %), mSAD(manual 12.7 %; semi-automatic 5.7 %) and EASL (manual 10.4 %; semi-automatic 1.8 %). The difference in established parameters was not statistically noticeable (p > 0.05). The ICCs of LAD (manual 0.984; semi-automatic 0.982), SAD (manual 0.975; semi-automatic 0.958) and WHO (manual 0.984; semi-automatic 0.978) are high, both in manual and semi-automatic measurements. The ICCs of manual measurements of mLAD (0.897), mSAD(0.844) and EASL (0.875) are lower. This decrease cannot be found in semi-automatic measurements of mLAD (0.997), mSAD(0.992) and EASL (0.998). Conclusion Vitality-based tumor measurements of HCC and metastases after transarterial local therapies should be performed semi-automatically due to greater measurement precision, thus increasing the reproducibility and in turn the reliability of therapeutic decisions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoeink, Anna Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuelke, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Loehnert, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Kammerer, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Fortkamp, Rasmus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindel, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerke, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211867
DOI:	10.1055/s-0043-116220
Journal or Publication Title:	Rofo-Fortschr. Gebiet Rontgenstrahlen Bildgeb. Verfahr.
Volume:	189
Number:	11
Page Range:	S. 1067 - 1076
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-9010
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPH-NODE METASTASES; HEPATOCELLULAR-CARCINOMA; VOLUMETRIC-ANALYSIS; TUMOR RESPONSE; SOLID TUMORS; LUNG-CANCER; SEGMENTATION; MSCT; CHEMOEMBOLIZATION; REPRODUCIBILITY Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21186