Universität zu Köln

Pircher, Andreas ORCID: 0000-0002-7747-3012, Wolf, Dominik, Heidenreich, Axel, Hilbe, Wolfgang, Pichler, Renate and Heidegger, Isabel (2017). Synergies of Targeting Tumor Angiogenesis and Immune Checkpoints in Non-Small Cell Lung Cancer and Renal Cell Cancer: From Basic Concepts to Clinical Reality. Int. J. Mol. Sci., 18 (11). BASEL: MDPI. ISSN 1422-0067

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Abstract

In recent years, considerable advances concerning therapeutic strategies in patients with metastatic cancer have been achieved. Particularly in renal cell cancer (RCC) and advanced stage non-small cell lung cancer (NSCLC), immune-activating and antiangiogenic (AA) drugs (i.e., checkpoint antibodies and vascular endothelial growth factor (VEGF)/VEGF receptors (VEGFR) targeting compounds, respectively) have been successfully developed. As immune-effector cells have to enter the tumor, it is tempting to speculate that the combination of immunotherapy with AA treatment may induce synergistic effects. In this short review, we explore the theoretical background and the therapeutic potential of this novel treatment option for patients with advanced RCC or NSCLC. We discuss the growing body of evidence that pro-angiogenic factors negatively modulate the T-cell-mediated immune response and examine the preclinical evidence for testing combined immune-activating and AA therapy concepts in clinical practice. Particular attention will also be paid to potential novel treatment-related adverse events induced by combination treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pircher, Andreas UNSPECIFIED orcid.org/0000-0002-7747-3012 UNSPECIFIED Wolf, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilbe, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Pichler, Renate UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidegger, Isabel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-211920
DOI:	10.3390/ijms18112291
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	18
Number:	11
Date:	2017
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VESSEL NORMALIZATION; BEVACIZUMAB BEV; CARCINOMA MRCC; OPEN-LABEL; COMBINATION; NIVOLUMAB; THERAPY; MICROENVIRONMENT; IMMUNOTHERAPY; INFILTRATION Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21192