Universität zu Köln

Schmidt, Nina, Grammer, Tanja, Gouni-Berthold, Ioanna, Julius, Ulrich, Kassner, Ursula, Klose, Gerald, Koenig, Christel, Laufs, Ulrich, Otte, Britta, Steinhagen-Thiessen, Elisabeth, Wanner, Christoph and Maerz, Winfried (2017). CaRe high - Cascade screening and registry for high cholesterol in Germany. Atheroscler. Suppl., 30. S. 72 - 77. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-5050

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Abstract

Introduction: Familial hypercholesterolemia (FH) is an inherited disorder of the LDL metabolism, leading to cardiovascular disease, even at young age. This risk can be significantly lowered by early diagnosis and treatment. About 270,000 patients affected in Germany are not diagnosed correctly and only a small number is treated properly. To improve FH diagnosis in the general population a cascade screening and registry data is warranted, yet missing in Germany. This project aims to fill this gap. Methods: Study assistants approach physicians and lipid clinics to introduce the cascade screening and registry. The physicians identify potential FH patients and include them in the study. Patient data is acquired via questionnaires about medical history. Patients meeting at least two inclusion criteria (LDL-C > 190 mg/dl or total cholesterol > 290 mg/dl; tendon xanthomas; family history of hypercholesterolemia or early myocardial infarction) are included in the registry. Family members will be contacted and physicians get feedback about diagnosis and treatment options. Ethical approvals for all German states have been collected. Results: So far physicians, lipid clinics and patients within the Rhein-Neckar region, the Saarland, North-Rhine-Westphalia, Upper Bavaria, Bremen, Saxonia and Berlin have joined the study. We expect to include more than 3000 patients during the next two years. Conclusion: After initial patient and data collection the project aims to improve FH-diagnosis and treatment. Utilizing registry data might advance diagnostic criteria and improve detection of FH and thus prevent CVD in this population. (C) 2017 Published by Elsevier Ireland Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Grammer, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Julius, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassner, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Klose, Gerald UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Christel UNSPECIFIED UNSPECIFIED UNSPECIFIED Laufs, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Otte, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinhagen-Thiessen, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Wanner, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Maerz, Winfried UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-212016
DOI:	10.1016/j.atherosclerosissup.2017.05.015
Journal or Publication Title:	Atheroscler. Suppl.
Volume:	30
Page Range:	S. 72 - 77
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-5050
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASSOCIATION EXPERT PANEL; PATIENTS CLINICAL GUIDANCE; FAMILIAL HYPERCHOLESTEROLEMIA; HEART-DISEASE; RECEPTOR; DIAGNOSIS; PATHOGENESIS; PREVALENCE; MANAGEMENT; MUTATIONS Multiple languages Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21201