Universität zu Köln

Nowag, A., Platten, M., Plum, G. and Hartmann, P. (2017). Nontuberculous mycobacterial infections. Z. Rheumatol., 76 (9). S. 752 - 761. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1435-1250

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Abstract

Nontuberculous mycobacterial (NTM) are found ubiquitously in the environment and are usually of low pathogenicity. Infection occurs via inhalation of aerosols, and some species may cause severe infections. The incidence of NTM infections is rising worldwide. The risk of developing NTM disease depends on the susceptibility of the host as well as the frequency and duration of exposure. In addition to congenital immune deficiencies and immunosuppressive therapy, structural lung and systemic diseases, including rheumatoid arthritis (RA), are associated with an increased risk for NTM infections. The immune response to NTM is complex and relies on the interplay between professional phagocytes and lymphoid cells. This interplay is concerted by three key cytokines: interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). Targeted immunotherapies, e. g., treatment with TNF inhibitors, interfere with these essential pathways and increase the risk of NTM infection significantly. This review focuses on the relationship between the immune response to NTM and intrinsic and iatrogenic dispositions for NTM infection, with an emphasis on RA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nowag, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Platten, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Plum, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-212639
Journal or Publication Title:	Z. Rheumatol.
Volume:	76
Number:	9
Page Range:	S. 752 - 761
Date:	2017
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1435-1250
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IFN-GAMMA AUTOANTIBODY; RHEUMATOID-ARTHRITIS; INTERFERON-GAMMA; INFLAMMATORY DISEASES; TUBERCULOSIS; PATIENT; RISK; SUSCEPTIBILITY; THERAPY; IMMUNODEFICIENCY Multiple languages Rheumatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21263