Universität zu Köln

Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Filss, Christian ORCID: 0000-0002-9927-6335, Heinzel, Alexander, Stegmayr, Carina ORCID: 0000-0003-4191-8734, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Willuweit, Antje ORCID: 0000-0002-6725-0755, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Mottaghy, Felix M. and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2017). Imaging of amino acid transport in brain tumours: Positron emission tomography with O-(2-[F-18]fluoroethyl)-L-tyrosine (FET). Methods, 130. S. 124 - 135. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9130

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Abstract

The assessment of cerebral gliomas using magnetic resonance imaging (MRI) provides excellent structural images but cannot solve all diagnostic problems satisfactorily. The differentiation of tumour tissue from non-neoplastic changes may be difficult especially in the post-treatment phase. In recent years, positron emission tomography (PET) using radiolabelled amino acids has gained considerable interest as an additional tool to improve the diagnosis of cerebral gliomas and brain metastases. A key step for this advancement was the development of the F-18 labelled amino acid. O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) which has spread rapidly in the last decade and replaced carbon-11 labelled amino acid tracers such as C-11-methyl-L-methionine (MET) in many centres in Europe. FET can be produced with high efficiency and distributed in a satellite concept like 2-[F-18]fluoro-2-deoxy-D-glucose (FDG). Furthermore, FET exhibits favourable properties such as high in vivo stability, high tumour to background contrast and tissue specific tracer kinetics, which provides additional information for tumour grading or differential diagnosis. The Response Assessment in Neuro-Oncology (RANO) working group - an international effort to develop new standardized response criteria for clinical trials in brain tumours - has recently recommended the additional use of amino acid PET imaging for brain tumour management. FET PET can provide important diagnostic information in crucial situations such as the definition of biopsy site, the delineation of cerebral gliomas for therapy planning, sensitive monitoring of treatment response and an improved differentiation of tumour recurrence from treatment-related changes. In this article the basic information, methodological aspects and the actual status of clinical application of FET PET are reviewed. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Heinzel, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Stegmayr, Carina UNSPECIFIED orcid.org/0000-0003-4191-8734 UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Willuweit, Antje UNSPECIFIED orcid.org/0000-0002-6725-0755 UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Mottaghy, Felix M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213609
DOI:	10.1016/j.ymeth.2017.05.019
Journal or Publication Title:	Methods
Volume:	130
Page Range:	S. 124 - 135
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9130
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DYNAMIC F-18-FET PET; VALUABLE DIAGNOSTIC-TOOL; LOW-GRADE GLIOMA; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; UPTAKE KINETICS; PROGNOSTIC VALUE; RESPONSE ASSESSMENT; DIFFERENTIAL UPTAKE; CLINICAL-EVALUATION; RADIATION NECROSIS Multiple languages Biochemical Research Methods; Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21360