Universität zu Köln

Achilles, Elisabeth I. S., Weiss, Peter H. ORCID: 0000-0002-5230-9080, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Binder, Ellen, Price, Cathy J. and Hope, Thomas M. H. (2017). Using multi-level Bayesian lesion-symptom mapping to probe the body-part-specificity of gesture imitation skills. Neuroimage, 161. S. 94 - 104. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Past attempts to identify the neural substrates of hand and finger imitation skills in the left hemisphere of the brain have yielded inconsistent results. Here, we analyse those associations in a large sample of 257 left hemisphere stroke patients. By introducing novel Bayesian methods, we characterise lesion symptom associations at three levels: the voxel-level, the single-region level (using anatomically defined regions), and the region-pair level. The results are inconsistent across those three levels and we argue that each level of analysis makes assumptions which constrain the results it can produce. Regardless of the inconsistencies across levels, and contrary to past studies which implicated differential neural substrates for hand and finger imitation, we find no consistent voxels or regions, where damage affects one imitation skill and not the other, at any of the three analysis levels. Our novel Bayesian approach indicates that any apparent differences appear to be driven by an increased sensitivity of hand imitation skills to lesions that also impair finger imitation. In our analyses, the results of the highest level of analysis (region-pairs) emphasise a role of the primary somatosensory and motor cortices, and the occipital lobe in imitation. We argue that this emphasis supports an account of both imitation tasks based on direct sensor-motor connections, which throws doubt on past accounts which imply the need for an intermediate (e.g. body-part-coding) system of representation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Achilles, Elisabeth I. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Price, Cathy J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hope, Thomas M. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213629
DOI:	10.1016/j.neuroimage.2017.08.036
Journal or Publication Title:	Neuroimage
Volume:	161
Page Range:	S. 94 - 104
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE STROKE PATIENTS; IDEOMOTOR APRAXIA; INTERINDIVIDUAL VARIABILITY; HYPOTHESIS TEST; PRIMARY MOTOR; PARIETAL; CORTEX; BRAIN; HEMISPHERE; AREAS Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21362