Universität zu Köln

Necchi, Andrea ORCID: 0000-0002-3007-2756, Pond, Gregory R., Raggi, Daniele ORCID: 0000-0003-4105-9968, Ottenhof, Sarah R., Djajadiningrat, Rosa S., Horenblas, Simon, Khoo, Vincent, Hakenberg, Oliver W., Draeger, Desiree, Protzel, Chris, Heidenreich, Axel, Haidl, Friederike, Eigl, Bernie J., Nappi, Lucia, Matsumoto, Kazumasa, Vaishampayan, Ulka ORCID: 0000-0001-5800-4571, Woods, Michael E., Salvioni, Roberto ORCID: 0000-0001-7581-5421, Nicolai, Nicola ORCID: 0000-0002-5718-2699, Catanzaro, Mario, Giannatempo, Patrizia ORCID: 0000-0002-3358-4466, Geynisman, Daniel M., Preto, Mirko ORCID: 0000-0002-8144-6498, Xylinas, Evanguelos, Milowsky, Matthew I., De Placido, Sabino, Di Lorenzo, Giuseppe ORCID: 0000-0001-7414-1568 and Sonpavde, Guru (2017). Clinical Outcomes of Perioperative Chemotherapy in Patients With Locally Advanced Penile Squamous-Cell Carcinoma: Results of a Multicenter Analysis. Clin. Genitourin. Cancer, 15 (5). S. 548 - 559. DALLAS: CIG MEDIA GROUP, LP. ISSN 1938-0682

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Abstract

Patients with locally advanced penile squamous-cell carcinoma have a poor prognosis. No difference in survival was noted when using chemotherapy before or after surgery. Uncertainties persist regarding the optimal management of these patients, and new treatments are urgently required, particularly for patients at highest risk, with bilateral and/or pelvic lymph node involvement. Background: The prognosis of patients with locally advanced penile squamous-cell carcinoma is primarily related to the extent of lymph node metastases. Surgery alone yields suboptimal results, and there is a paucity of data on these patients' outcomes. Patients and Methods: This retrospective study evaluated patients who received neoadjuvant or adjuvant chemotherapy from 1990 onward at 12 centers. Cox models were used to investigate prognostic factors for relapse-free survival and overall survival (OS). Results: Among the 201 included patients, 39 (19.4%) had disease of T3-4 and N0 clinical stage; the remaining patients had clinical lymph node involvement (cN+). Ninety-four patients received neoadjuvant chemotherapy (group 1), 78 received adjuvant chemotherapy (group 2), and 21 received both (group 3). Eight patients for whom the timing of perioperative chemotherapy administration was unavailable were included in the Cox analyses. Forty-three patients (21.4%) received chemoradiation. Multivariate analysis for OS (n = 172) revealed bilateral disease (P = .035) as a negative prognostic factor, while pelvic cN+ tended to be nonsignificantly associated with decreased OS (P = .076). One-year relapse-free survival was 35.6%, 60.6%, and 45.1% in the 3 groups, respectively. One-year OS was 61.3%, 82.2%, and 75%, respectively. No significant differences were seen on univariable analyses for OS between the groups (P = .45). Platinum type of chemotherapy and chemoradiation were not significantly associated with any outcome analyzed. Conclusion: Benchmark survival estimates for patients receiving perioperative chemotherapy for locally advanced penile squamous-cell carcinoma have been provided, with no substantial differences observed between neoadjuvant and adjuvant administration. This analysis may result in improved patient information, although prospective studies are warranted. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Necchi, Andrea UNSPECIFIED orcid.org/0000-0002-3007-2756 UNSPECIFIED Pond, Gregory R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Raggi, Daniele UNSPECIFIED orcid.org/0000-0003-4105-9968 UNSPECIFIED Ottenhof, Sarah R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Djajadiningrat, Rosa S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horenblas, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Khoo, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Hakenberg, Oliver W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Draeger, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Protzel, Chris UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Eigl, Bernie J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nappi, Lucia UNSPECIFIED UNSPECIFIED UNSPECIFIED Matsumoto, Kazumasa UNSPECIFIED UNSPECIFIED UNSPECIFIED Vaishampayan, Ulka UNSPECIFIED orcid.org/0000-0001-5800-4571 UNSPECIFIED Woods, Michael E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salvioni, Roberto UNSPECIFIED orcid.org/0000-0001-7581-5421 UNSPECIFIED Nicolai, Nicola UNSPECIFIED orcid.org/0000-0002-5718-2699 UNSPECIFIED Catanzaro, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Giannatempo, Patrizia UNSPECIFIED orcid.org/0000-0002-3358-4466 UNSPECIFIED Geynisman, Daniel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Preto, Mirko UNSPECIFIED orcid.org/0000-0002-8144-6498 UNSPECIFIED Xylinas, Evanguelos UNSPECIFIED UNSPECIFIED UNSPECIFIED Milowsky, Matthew I. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Placido, Sabino UNSPECIFIED UNSPECIFIED UNSPECIFIED Di Lorenzo, Giuseppe UNSPECIFIED orcid.org/0000-0001-7414-1568 UNSPECIFIED Sonpavde, Guru UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215103
DOI:	10.1016/j.clgc.2017.02.002
Journal or Publication Title:	Clin. Genitourin. Cancer
Volume:	15
Number:	5
Page Range:	S. 548 - 559
Date:	2017
Publisher:	CIG MEDIA GROUP, LP
Place of Publication:	DALLAS
ISSN:	1938-0682
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPH-NODE DISSECTION; CANCER; NEOADJUVANT; EXPERIENCE; CISPLATIN; SURVIVAL Multiple languages Oncology; Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21510