Universität zu Köln

Haufe, S., Engeli, S., Kaminski, J., Witt, H., Rein, D., Kamlage, B., Utz, W., Fuhrmann, J. C., Haas, V., Maehler, A., Schulz-Menger, J., Luft, F. C., Boschmann, M. and Jordan, J. (2017). Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals. Nutr. Metab. Carbiovasc. Dis., 27 (10). S. 858 - 865. OXFORD: ELSEVIER SCI LTD. ISSN 1590-3729

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Abstract

Background & aims: 3-Hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, which stimulates muscle fatty acid uptake, has been implicated in the pathogenesis of insulin resistance. We tested the hypothesis that circulating 3-HIB herald insulin resistance and that metabolic improvement with weight loss are related to changes in BCAAs and 3-HIB. Methods and results: We analyzed plasma and urine in 109 overweight to obese individuals before and after six months on hypocaloric diets reduced in either carbohydrates or fat. We calculated the homeostasis model assessment index (HOMA-IR) and whole body insulin sensitivity from oral glucose tolerance tests and measured intramyocellular fat by magnetic resonance spectroscopy. BCAAs and 3-HIB plasma concentrations were inversely related to insulin sensitivity but not to intramyocellular fat content at baseline. With 7.4 +/- 4.5% weight loss mean BCAA and 3-HIB plasma concentrations did not change, irrespective of dietary macronutrient content. Individual changes in 3-HIB with 6-month diet but not BCAAs were correlated to the change in whole body insulin sensitivity and HOMA-IR independently of BMI changes. Conclusions: 3-HIB relates to insulin sensitivity but is not associated with intramyocellular fat content in overweight to obese individuals. Moreover, changes in 3-HIB rather than changes in BCAAs are associated with metabolic improvements with weight loss. (C) 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haufe, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engeli, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaminski, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rein, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamlage, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Utz, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuhrmann, J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maehler, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz-Menger, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Luft, F. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boschmann, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215872
DOI:	10.1016/j.numecd.2017.07.001
Journal or Publication Title:	Nutr. Metab. Carbiovasc. Dis.
Volume:	27
Number:	10
Page Range:	S. 858 - 865
Date:	2017
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1590-3729
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPPLEMENTATION; METABOLISM; PROTEIN; RISK; 3-HYDROXYISOBUTYRATE; CONTRIBUTES; MECHANISMS; OXIDATION; PROFILES; LEUCINE Multiple languages Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21587