Moustakis, Christos ORCID: 0000-0002-8879-2350, Blanck, Oliver ORCID: 0000-0003-1391-1308, Tazehmahalleh, Fatemeh Ebrahimi, ka heng Chan, Mark, Ernst, Iris, Krieger, Thomas, Duma, Marciana-Nona, Oechsner, Markus, Ganswindt, Ute ORCID: 0000-0003-4492-614X, Heinz, Christian, Alheit, Horst, Blank, Hilbert, Nestle, Ursula, Wiehle, Rolf, Kornhuber, Christine, Ostheimer, Christian, Petersen, Cordula, Pollul, Gerhard, Baus, Wolfgang, Altenstein, Georg, Beckers, Eric, Jurianz, Katrin, Sterzing, Florian, Kretschmer, Matthias, Seegenschmiedt, Heinrich, Maass, Torsten, Droege, Stefan, Wolf, Ulrich, Schoeffler, Juergen, Haverkamp, Uwe, Eich, Hans Theodor and Guckenberger, Matthias ORCID: 0000-0002-7146-9071 (2017). Planning benchmark study for SBRT of early stage NSCLC. Strahlenther. Onkol., 193 (10). S. 780 - 791. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Purpose The aim was to evaluate stereotactic body radiation therapy (SBRT) treatment planning variability for early stage nonsmall cell lung cancer (NSCLC) with respect to the published guidelines of the Stereotactic Radiotherapy Working Group of the German Society for Radiation Oncology (DEGRO). Materials and methods Planning computed tomography (CT) scan and the structure sets (planning target volume, PTV; organs at risk, OARs) of 3 patients with early stage NSCLC were sent to 22 radiotherapy departments with SBRT experience: each department was asked to prepare a treatment plan according to the DEGRO guidelines. The prescription dose was 3 fractions of 15 Gy to the 65% isodose. Results In all, 87 plans were generated: 36 used intensity-modulated arc therapy (IMAT), 21 used three-dimensional conformal radiation therapy (3DCRT), 6 used static field intensity-modulated radiation therapy (SF-IMRT), 9 used helical radiotherapy and 15 used robotic radiosurgery. PTV dose coverage and simultaneously kept OARs doses were within the clinical limits published in the DEGRO guidelines. However, mean PTV dose (mean 58.0 Gy, range 52.8-66.4 Gy) and dose conformity indices (mean 0.75, range 0.60-1.00) varied between institutions and techniques (p <= 0.02). OARs doses varied substantially between institutions, but appeared to be technique independent (p = 0.21). Conclusion All studied treatment techniques are well suited for SBRT of early stage NSCLC according to the DEGRO guidelines. Homogenization of SBRT practice in Germany is possible through the guidelines; however, detailed treatment plan characteristics varied between techniques and institutions and further homogenization is warranted in future studies and recommendations. Optimized treatment planning should always follow the ALARA (as low as reasonably achievable) principle.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Moustakis, ChristosUNSPECIFIEDorcid.org/0000-0002-8879-2350UNSPECIFIED
Blanck, OliverUNSPECIFIEDorcid.org/0000-0003-1391-1308UNSPECIFIED
Tazehmahalleh, Fatemeh EbrahimiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
ka heng Chan, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ernst, IrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieger, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duma, Marciana-NonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oechsner, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ganswindt, UteUNSPECIFIEDorcid.org/0000-0003-4492-614XUNSPECIFIED
Heinz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alheit, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blank, HilbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nestle, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiehle, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostheimer, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petersen, CordulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pollul, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baus, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenstein, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckers, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jurianz, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sterzing, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretschmer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seegenschmiedt, HeinrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maass, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Droege, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoeffler, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haverkamp, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eich, Hans TheodorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guckenberger, MatthiasUNSPECIFIEDorcid.org/0000-0002-7146-9071UNSPECIFIED
URN: urn:nbn:de:hbz:38-216002
DOI: 10.1007/s00066-017-1151-8
Journal or Publication Title: Strahlenther. Onkol.
Volume: 193
Number: 10
Page Range: S. 780 - 791
Date: 2017
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-099X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CELL LUNG-CANCER; STEREOTACTIC BODY RADIOTHERAPY; RADIATION-THERAPY; TREATMENT PLANS; CONFORMITY; INDEX; BRACHYTHERAPY; OPTIMIZATION; IRRADIATION; PROSTATEMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21600

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